actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-805Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEОСОБЕННОСТИ АССОЦИАЦИИ ПОЛИМОРФНЫХ МАРКЕРОВ -251 Т>А ГЕНА IL-8 И ПОЛИМОРФИЗМ ГЕНОВ HELICOBACTER PYLORI У КОРЕННЫХ И ПРИШЛЫХ ЖИТЕЛЕЙ ХАКАСИИPECULIARITIES OF AN ASSOCIATION OF POLYMORPHOUS MARKERS -251 Т>А OF IL-8 GENE AND POLYMORPHISM OF HELICOBACTER PYLORI GENES IN NATIVE AND VISITANT POPULATION OF THE REPUBLIC OF KHAKASSIAАгееваЕ. С.AgeevaE. S.Ageevaeliz@rambler.ruШтыгашеваО. В.ShtygashevaO. V.noemail@neicon.ruФГБОУ ВПО «Хакасский государственный университет им. Н.Ф. Катанова»Khakas State University named after N.F. Katanov20122804201202(2)912Copyright © Агеева Е.С., Штыгашева О.В., 20122012Агеева Е.С., Штыгашева О.В.Ageeva E.S., Shtygasheva O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/805

Исследовали полиморфизм гена интерлейкина IL-8 при Helicobacter pylori-ассоциированных заболеваниях: язвенной болезни и хроническом, гастрите у коренных и пришлых жителей Хакасии методом рестрикционного анализа. Распространенность субтипов VacA+ и. CagA+ Helicobacter pylori проводили методом, полимеразной цепной реакции. Выявлены, наиболее распространенные аллельные варианты генов цитокинов среди, хакасов. Обсуждается, целесообразность определения популяционных рисковых и. протективных генотипов Helicobacter pylori, способствующих развитию язвенной болезни у хакасов.

We researched, polymorphism, of interleukin IL-8 gene at Helicobacter pylori-associated diseases: ulcers and chronic gastritis in native and visitant population of the Republic of Khakassia by the method, of restriction enzyme digest analysis. Prevalence of subtypes VacA+ and CagA+ of Helicobacter pylori was realized, by the method, of polymerase chain reaction. We revealed, the most widespread allelic variants of genes of cytokines among Khakas. The expediency of determination, of population, risk and. protective genotypes of Helicobacter pylori that promote development of ulcer desease in Khakas.

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The authors declare that there are no conflicts of interest present.