Polymorphism of apolipoprotein A1 gene and lipid profile of blood serum in the Evenki and Buryat populations
Abstract
The prevalence of genotypes and alleles of polymorphic markers (-75)G>A and (+83)C>T apolipoprotein A1 gene (ApOAl) in samples of ethnic groups from Eastern Siberia (the Evenkis and Buryats) were studied. In the Evenki population allele (-75)A was registered in 22,7 % cases, in the Buryat population - in 22,4 % cases. In the Evenki population allele (+83)T was found in 6,3 % cases, in the Buryat population - in 5,9 % cases. Statistically significant differences of genotypes and alleles APOA1 prevalence between the Evenkis and the Buryats was not found. The prevalence of alleles (-75)G>A and (+83)C>T of gene APOA1 obtained in the study were compared with the prevalence in different populations around the world. For each teenager in the study group we conducted a biochemical analysis of serum lipid profile. Also a comparative analysis of blood lipid profile in carriers of different genotypes was carried out. Comparative analysis of blood lipid profile in carriers of different genotypes was conducted.
About the Authors
S. I. Kolesnikov
Russian Academy of Sciences
Russian Federation
Russian Federation
T. A. Bairova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
O. V. Kalyuzhnaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
A. A. Trukhin
Russian Academy of Sciences
Russian Federation
Russian Federation
O. A. Ershova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
M. A. Darenskaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Колесникова Л.И., Баирова Т.А., Первушина О.А. Этногенетические маркеры антиоксидантной системы (обзор литературы) // Бюлл. ВСНЦ СО РАМН. - 2013. - № 4 (92). - С. 166-171
2. Колесникова Л.И., Даренская М.А., Гребенкина Л.А., Лабыгина А.В., Долгих М.И., Натяганова Л.В., Первушина О.А. Проблемы этноса в медицинских исследованиях (обзор литературы) // Бюлл. ВСНЦ СО РАМН. - 2013. - № 4 (92). - С. 153-159
3. Творогова М.Г. Аполипопротеины - свойства, методы определения, клиническая значимость // Лабораторная медицина. - 2005. - № 7. - С. 29-37
4. Coban N, Onat A, Guclu-Geyik F, Evrim Komurcu-Bayrak E, Can G, Erginel-Unaltuna N (2014). Gender-specific associations of the APOA1 -75G>A polymorphism with several metabolic syndrome components in Turkish adults. Clinica Acta., 431, 244-249
5. Dawar R, Gurtoo A, Singh R (2010). Apolipoprotein A1 gene polymorphism (G-75A and C+83T) in patients with myocardial infarction. A pilot study in a North Indian population. Am. J. Clin. Pathol., 134, 249-255
6. De França E, Alves JGB, Hutz MH (2005). APOA1 / C3 / A4 gene cluster variability and lipid levels in Brazilian children. Braz. J. Med. Biol. Res., 38, 535-541
7. Fielding CJ, Fielding PE (1995). Molecular physiology of reverse cholesterol transport. J. Lipid Research., 36, 211-228
8. GeneCards (2015), http: www.genecards.org
9. Gomez P, Perez-Martinez P, Marin C, Camargo A, Yubero-Serrano EM (2010). APOA1 and APOA4 gene polymorphisms influence the effects of dietary fat on LDL particle size and oxidation in healthy young adults. J. Nutr., 140, 773-778
10. Hamrita B, Nasr HB, Gabbouj S, Chouchane L, Chahed K (2011). Apolipoprotein A1 -75G/A and +83C/T polymorphisms: susceptibility and prognostic implications in breast cancer. Mol. Biol. Rep., 38, 16371643
11. Heng CK, Low PS, Saha N (2001). Variations in the promoter region of the apolipoprotein A-1 gene influence plasma lipoprotein(a) levels in Asian Indian neonates from Singapore. Pediatric Research., 49 (4), 514-518
12. Kamboh MI, Bunker CH, Aston CE, Nestlerode CS, McAllister AE, Ukoli FA (1999). Genetic association of five apolipoprotein polymorphisms with serum lipoprotein-lipid levels in African blacks. Genetic Epidemiology., 16, 205-222
13. Padmaja N, Kumar MR, Adithan C (2009). Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian population. Indian Heart J., 61 (1), 51-54
14. Tu J, Zhang B, Chen Y Liang B, Liang D, Liu G, He F (2013). Association of apolipoprotein A1 -75G/A polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery. Lipids in Health and Disease, 12 (172), 1-5
15. Villard EF, Khoury PE, Frisdal E, Bruckert E, Clement K (2013). Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels. Arterioscler. Thromb. Vasc. Biol., 3, 822-828
16. Vollbach H, Heun R, Morris CM, Vollbach H, Heun R, Morris CM, Edwardson JA, McKeith IJ, Jessen F (2005). APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Ann. Neurol., 58, 436-441
17. Wang XL, Badenhop R, Humphrey KE, Wilcken DE (1996). New Mspl polymorphism at +83bp of the human apolipoprotein Al gene: association with increased circulating high density lipoprotein cholesterol levels. Genetic Epidemiology, 1, l-10
18. Wang XL, Liu SX, McCredie RM, Wilcken DE (1996). Polymorphisms at the 5-end of the apolipoprotein A-I gene and severity of coronary artery disease. J. Clin. Invest., 98 (2), 372-377
Review
For citations:
Kolesnikov S.I., Bairova T.A., Kalyuzhnaya O.V., Trukhin A.A., Ershova O.A., Darenskaya M.A. Polymorphism of apolipoprotein A1 gene and lipid profile of blood serum in the Evenki and Buryat populations. Acta Biomedica Scientifica. 2015;(3):74-78. (In Russ.)
Views:
581
.png)
Email this article 
