actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-75Research ArticleГЕНОМИКА И ПРОТЕОМИКАGENOMICS AND PROTEOMICSПолиморфизм гена аполипопротеина А1 и липидный спектр сыворотки крови в популяциях эвенков и бурятPolymorphism of apolipoprotein A1 gene and lipid profile of blood serum in the Evenki and Buryat populationsКолесниковС. И.KolesnikovS. I.noemail@neicon.ruБаироваТ. А.BairovaT. A.noemail@neicon.ruКалюжнаяО. В.KalyuzhnayaO. V.noemail@neicon.ruТрухинА. А.TrukhinA. A.noemail@neicon.ruЕршоваО. А.ErshovaO. A.noemail@neicon.ruДаренскаяМ. А.DarenskayaM. A.noemail@neicon.ruРоссийская академия наукRussian Academy of SciencesФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»Scientific Centre for Family Health and Human Reproduction Problems201528052015037478Copyright © Колесников С.И., Баирова Т.А., Калюжная О.В., Трухин А.А., Ершова О.А., Даренская М.А., 20152015Колесников С.И., Баирова Т.А., Калюжная О.В., Трухин А.А., Ершова О.А., Даренская М.А.Kolesnikov S.I., Bairova T.A., Kalyuzhnaya O.V., Trukhin A.A., Ershova O.A., Darenskaya M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/75

Изучена распространенность генотипов и аллелей полиморфных маркеров (-75)G>A и (+83)C>T гена аполипопротеина А1 (APOA1) в выборках из двух этнических групп Восточной Сибири: эвенков и бурят. Доля аллеля (-75)Aу эвенков составила 22,7 %, у бурят - 22,4 %. Доля аллеля (+83)T в группе эвенков - 6,3 %, в группе бурят - 5,9 %. Статистически значимых отличий распространенности генотипов и аллелей гена AРOA1 между эвенками и бурятами не выявлено. Проведен сравнительный анализ показателей липидограммы крови у носителей разных генотипов.

The prevalence of genotypes and alleles of polymorphic markers (-75)G>A and (+83)C>T apolipoprotein A1 gene (ApOAl) in samples of ethnic groups from Eastern Siberia (the Evenkis and Buryats) were studied. In the Evenki population allele (-75)A was registered in 22,7 % cases, in the Buryat population - in 22,4 % cases. In the Evenki population allele (+83)T was found in 6,3 % cases, in the Buryat population - in 5,9 % cases. Statistically significant differences of genotypes and alleles APOA1 prevalence between the Evenkis and the Buryats was not found. The prevalence of alleles (-75)G>A and (+83)C>T of gene APOA1 obtained in the study were compared with the prevalence in different populations around the world. For each teenager in the study group we conducted a biochemical analysis of serum lipid profile. Also a comparative analysis of blood lipid profile in carriers of different genotypes was carried out. Comparative analysis of blood lipid profile in carriers of different genotypes was conducted.

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The authors declare that there are no conflicts of interest present.