EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE
https://doi.org/10.29413/ABS.2018-3.5.20
Abstract
Regeneration of muscles after injuries, as well as the development of methods that stimulate this process, is an important problem in medicine and biology. The objective of the study was to evaluate the effect of local blocking of mitogen-activated protein kinase (MAPK) activity of the JNK group (c-Jun N-terminal kinase) on the repair of muscle tissue. Materials and methods. The effect of the JNK MAPK SP600125 blocker on the repair of muscle tissue was studied on a model of a skin and muscle wound in Wistar rats. The main group (n = 30) was injected with a drug plate containing SP600125 with a slow release of the active substance, the control group (n = 30) – the plate without the active substance. The number of dividing myosatellites and muscle kidneys in the damage zone was estimated. Results. Experimental studies have shown that when using a drug plate containing a JNK SP600125 blocker with a slow release of the active substance, the number of dividing myosatellites and forming muscle kidneys in the injury zone of the muscle in the main group on the 7th, 14th and 30th days was significantly higher (p < 0.05) than in the control. Conclusion. Local blockade of JNK MAPK in the zone of muscle damage provides the ability to stimulate the repair of damaged skeletal muscle.
About the Authors
I. A. Shurygina
Irkutsk Scientific Centre of Surgery and Traumatology.
Russian Federation
Russian Federation
ul. Bortsov Revolutsii 1, Irkutsk 664003.
Doctor of Medical Sciences, Professor of RAS, Deputy Director for Science.
M. G. Shurygin
Irkutsk Scientific Centre of Surgery and Traumatology.
Russian Federation
Russian Federation
ul. Bortsov Revolutsii 1, Irkutsk 664003.
Doctor of Medical Sciences, Head of the Scientific Laboratory Department.
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Review
For citations:
Shurygina I.A., Shurygin M.G. EFFECT OF JNK MAPK ON THE REPAIR OF DAMAGED SKELETAL MUSCLE. Acta Biomedica Scientifica. 2018;3(5):137-140. (In Russ.) https://doi.org/10.29413/ABS.2018-3.5.20
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