Efficacy of laser nucleoplasty and radiofrequency neuromodulation in the treatment of discogenic lumbar radiculopathy
https://doi.org/10.29413/ABS.2024-9.6.14
Abstract
Back and lower limb pain interferes with patients’ daily lives and ultimately reduces their quality of life. Many interventional treatments have been proposed to reduce and prevent the development of chronic pain syndrome.
The aim of the study. To evaluate the effectiveness of the simultaneous use of laser nucleoplasty and radiofrequency neuromodulation of radicular nerves and ganglia in the treatment of discogenic lumbar radiculopathy.
Materials and methods. The study included 20 patients; the mean age was 39 ± 9.1 years. All patients underwent laser nucleoplasty of the LIV/LV intervertebral disc and radiofrequency neuromodulation of the radicular nerve in the foraminal space of the level of interest and localization of pain. An assessment of changes in pain intensity and quality of life was carried out according to scales in the preand postoperative period and a control magnetic resonance imaging (MRI) study at the time of discharge, 3 months of observation, with an assessment of the volumetric indicators of the intervertebral disc.
Results. Patients showed a decrease in pain intensity according to the Visual Analogue Scale and an improvement in quality of life assessed by the ODI (Oswestry Disability Index) and SF-36 (Short Form 36) questionnaires. According to MRI studies, volumetric indicators increased after surgery and subsequently decreased by the 3rd month of observation.
Conclusion. The study demonstrates the possibility of using several interventional treatment methods simultaneously with an impact on various morphological substrates that cause the formation of pain syndrome. It is shown that a decrease in the intensity of pain syndrome correlates with an increase in the volumetric indicators of the intervertebral disc according to MRI data immediately after surgery, with a subsequent decrease by 3 months of observation. Simultaneous use of laser nucleoplasty and radiofrequency neuromodulation is justified in the treatment of radiculopathy, allowing reducing the intensity of pain syndrome and increasing the volumetric indicators of the intervertebral disc, which is a sign that increases the shock-absorbing properties of the intervertebral disc.
About the Authors
S. N. LarionovRussian Federation
Sergey N. Larionov – Dr. Sc. (Med.), Leading Research Officer, Head of the Clinical Research Department of Neurosurgery,
Bortsov Revolyutsii str. 1, Irkutsk 664003;
A. P. Zhivotenko
Russian Federation
Aleksandr P. Zhivotenko – Research Officer at the Clinical Research Department of Neurosurgery,
Bortsov Revolyutsii str. 1, Irkutsk 664003
V. A. Sorokovikov
Russian Federation
Vladimir A. Sorokovikov – Dr. Sc. (Med.), Professor, Director, Bortsov Revolyutsii str. 1, Irkutsk 664003;
Head of the Department of Traumatology, Orthopedics and Neurosurgery, Yubileyny 100, Irkutsk 664049
A. V. Gorbunov
Russian Federation
Anatoly V. Gorbunov – Neurosurgeon at the Neurosurgical Department, Research Officer at the Clinical Research Department of Neurosurgery,
Bortsov Revolyutsii str. 1, Irkutsk 664003
V. E. Potapov
Russian Federation
Vitaly E. Potapov – Cand. Sc. (Med.), Senior Research Officer at the Clinical Research Department of Neurosurgery,
Bortsov Revolyutsii str. 1, Irkutsk 664003
References
1. Palada V, Ahmed AS, Finn A, Berg S, Svensson CI, Kosek E. Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease. Brain Behav Immun. 2019; 75: 60-71. doi: 10.1016/j.bbi.2018.09.010
2. Zhang YG, Guo TM, Guo X, Wu SX. Clinical diagnosis for discogenic low back pain. Int J Biol Sci. 2009; 5(7): 647-658. doi: 10.7150/ijbs.5.647
3. Baron R, Binder A, Attal N, Casale R, Dickenson AH, Treede RD. Neuropathic low back pain in clinical practice. Eur J Pain. 2016; 20(6): 861-873. doi: 10.1002/ejp.838
4. Itz CJ, Geurts JW, van Kleef M, Nelemans P. Clinical course of non-specific low back pain: A systematic review of prospective cohort studies set in primary care. Eur J Pain. 2013; 17(1): 5-15. doi: 10.1002/j.1532-2149.2012.00170.x
5. Bielewicz J, Kamieniak M, Szymoniuk M, Litak J, Czyżewski W, Kamieniak P. Diagnosis and management of neuropathic pain in spine diseases. J Clin Med. 2023; 12(4): 1380. doi: 10.3390/jcm12041380
6. Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010; 17: 1113- 1123. doi: 10.1111/j.1468-1331.2010.02999.x
7. Wu N, Liu H, Chen J, Zhao L, Zuo W, Ming Y, et al. Comparison of apparent diffusion coefficient and T2 relaxation time variation patterns in assessment of age and disc level related intervertebral disc changes. PLoS One. 2013; 8(7): e69052. doi: 10.1371/journal.pone.0069052
8. Alkalay R, David H. Diffusion based MR measurements correlates with age-related changes in human intervertebral disks. Clin Biomech (Bristol, Avon). 2019; 61: 38-45. doi: 10.1016/j.clinbiomech.2018.06.007
9. Potapov VE, Koshkareva ZV, Zhivotenko AP, Gorbunov AV, Sorokovikov VA. Puncture surgical technologies in the treatment of facet syndrome for spondylarthrosis in the lumbar spine (literature review). Acta biomedica scientifica. 2020; 5(2): 36-42. (In Russ.). doi: 10.29413/ABS.2020-5.2.6
10. Zileli M, Crostelli M, Grimaldi M, Mazza O, Anania C, Fornari M, et al. Natural course and diagnosis of lumbar spinal stenosis: WFNS Spine Committee recommendations. World Neurosurg X. 2020; 7: 100073. doi: 10.1016/j.wnsx.2020.100073
11. Sathish M, Eswar R. Systematic reviews and meta-analysis in spine surgery – How good are they in methodological quality? A systematic review. Global Spine J. 2021; 11(3): 378-399. doi: 10.1177/2192568220906810
12. Wan ZY, Shan H, Liu TF, Song F, Zhang J, Liu ZH, et al. Emerging issues questioning the current treatment strategies for lumbar disc herniation. Front Surg. 2022; 9: 814531. doi: 10.3389/fsurg.2022.814531
13. Xu X, Fu S, Shi X, Liu R. Microglial BDNF, PI3K, and p-ERK in the spinal cord are suppressed by pulsed radiofrequency on dorsal root ganglion to ease SNI-induced neuropathic pain in rats. Pain Res Manag. 2019; 2019: 5948686. doi: 10.1155/2019/5948686
14. Jang JN, Park S, Park JH, Song Y, Choi S, Kim YU, et al. Comparison of efficacy according to voltage of pulsed radiofrequency treatment to lumbar dorsal root ganglion in patient with lumbar radiculopathy: Pilot study. Medicine (Baltimore). 2023; 102(17): e33617. doi: 10.1097/MD.0000000000033617
15. Park S, Park JH, Jang JN, Choi SI, Song Y, Kim YU, et al. Pulsed radiofrequency of lumbar dorsal root ganglion for lumbar radicular pain: A systematic review and meta-analysis. Pain Pract. 2024; 24(5): 772-785. doi: 10.1111/papr.13351
16. Trinidad JM, Carnota AI, Failde I, Torres LM. Radiofrequency for the treatment of lumbar radicular pain: Impact on surgical indications. Pain Res Treat. 2015; 2015: 392856. doi: 10.1155/2015/392856
17. Facchini G, Spinnato P, Guglielmi G, Albisinni U, Bazzocchi A. A comprehensive review of pulsed radiofrequency in the treatment of pain associated with different spinal conditions. Br J Radiol. 2017; 90(1073): 20150406. doi: 10.1259/bjr.20150406
18. Zhivotenko AP, Koshkareva ZV, Gorbunov AV, Sorokovikov VA. Surgical treatment of facet syndrome in segmental instability of the lumbar spine. Acta biomedica scientifica. 2021; 6(3): 95-102. (In Russ.). doi: 10.29413/ABS.2021-6.3.10
19. Li C, Hou W, Ding D, Yang Y, Gu S, Zhu Y. Evidence mapping based on systematic reviews of cognitive behavioral therapy for neuropathic pain. Neural Plast. 2023; 2680620. doi: 10.1155/2023/2680620
20. Bates D, Schultheis BC, Hanes MC, Jolly SM, Chakravarthy KV, Deer TR, et al. A comprehensive algorithm for management of neuropathic pain. Pain Med. 2019; 20(Suppl 1): S2-S12. doi: 10.1093/pm/pnz075
21. Szewczyk AK, Jamroz-Wiśniewska A, Haratym N, Rejdak K. Neuropathic pain and chronic pain as an underestimated interdisciplinary problem. Int J Occup Med Environ Health. 2022; 35(3): 249-264. doi: 10.13075/ijomeh.1896.01676 22. Moisset X. Neuropathic pain: Evidence based recommendations. Presse Med. 2024; 53(2): 104232. doi: 10.1016/j.lpm.2024.104232
Review
For citations:
Larionov S.N., Zhivotenko A.P., Sorokovikov V.A., Gorbunov A.V., Potapov V.E. Efficacy of laser nucleoplasty and radiofrequency neuromodulation in the treatment of discogenic lumbar radiculopathy. Acta Biomedica Scientifica. 2024;9(6):138-148. (In Russ.) https://doi.org/10.29413/ABS.2024-9.6.14