Metabolism and obesity: role of leptin receptor gene
https://doi.org/10.12737/article_59e85cb55584e4.51145791
Abstract
Background. Currently more than 119 obesity-related polymorphisms is known to participate in adult obesity. One of them is LEPR Q223R. Many researches shown association of this polymorphism with adult obesity. However, the role of LEPR Q223R in adolescent overweight and obesity is the matter of dispute. Aim: to determine association of polymorphism Q223R of LEPR gene with some biochemical and hormonal measurements of blood in female adolescents with normal weight and with overweight and obesity. Materials and methods. A total of 103 female adolescents (14-17 years of age) was examined. All girls were divided into 2 groups: 43 girls with normal weight (SDS BM 10.311 ± 0.585), and 65 girls with overweight and obesity (SDS BMI 2.255± 0.739) (р < 0.0001). Height, weight, BM1, SDS BM1 were measured. Laboratory tests included triglycerides, total cholesterol and its fraction, TTH, free thyroxin and leptin. All girls were genotyped on carrier of LEPR Q223R. Statistical analysis was provided by software Statistica 8.0 using nonparametric Mann - Whitney methods and Chi-square test with Yates correction. Results. Significant association of carrying RR-genotype with increase of SDS BM1 (p = 0.006), THS (p = 0.006) and decrease of free thyroxin was shown in control group. Conclusion. Our results showed the association of R-allele with increase of SDS BM1, THS and decrease T4 free in control group.
About the Authors
K. D. Ievleva
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
T. A. Bairova
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
L. V. Rychkova
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
E. A. Sheneman
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
E. E. Khramova
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
L. I. Kolesnikova
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Загоруйко М.В., Бардымова Т.П., Рычкова Л.В. Ожирение у детей и подростков // Сибирский медицинский журнал (Иркутск). - 2010. - Т. 97, № 6. -С. 16-19
2. Иевлева К.Д., Рычкова Л.В., Шенеман Е.А., Баирова Т.А. Полиморфный локус Q223R гена LEPR и ожирение // Бюл. ВСНЦ СО РАМН. - 2016. - Т. 1, № 5 (111). - С. 170-174
3. Коваренко М.А., Руяткина Л.А., Петрищева М.С., Бодавели О.В. Лептин: физиологические и патологические аспекты действия // Вестник НГУ Серия Биология, клиническая медицина. - 2003. - Т. 1, Вып. 1. - С. 59-74
4. Панкрушина А.Н., Толстых К.Ю. Лептин: новые перспективы и подходы к коррекции ожирения // Вестник ТвГУ. Серия Биология и экология. - 2008. -Т. 10. - С. 27-34
5. Петеркова В.А., Ремизов О.В. Ожирение в детском возрасте // Ожирение и метаболизм. - 2004. -№ 1. - С. 17-23
6. Щербакова М.Ю., Порядина Г.И. Современный взгляд на проблему ожирения у детей и подростков // Педиатрия. - 2012. - Т. 91, № 3. - С. 122-130
7. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H., Lynn R.B., Zhang P.L., Sinha M.K. (1996). Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet, 20, 348 (9021), 159-161.
8. Choquet H., Meyre D. (2011). Genetics of obesity: what have we learned. Curr Genomics, 12 (3), 169-179.
9. Chiu K.C., Chu A., Chuang L.M., Saad M.F. (2004). Association of leptin receptor polymorphism with insulin resistance. Eur J Endocrinol, 150 (5), 725-729.
10. Dominguez-Reyes T., Astudillo-Lopez C.C., Salgado-Goytia L., Munoz-Valle J.F., Salgado-Bernabe A.B., Guzman-Guzman I.P., Castro-Alarcôn N., Moreno-Godi'nez M.E., Parra-Rojas I. (2015). Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects. Lipids Health Dis, 14, 106.
11. Farooqi I.S., Matarese G., Lord G.M., Keogh J.M., Lawrence E., Agwu C., Sanna V., Jebb S.A., Perna F., Fontana S., Lechler R.I., DePaoli A.M., O’Rahilly S. (2002). Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest, 110 (8), 10931103. doi: 10.1172/JCI15693.
12. Gahagan S. (2016). Overweight and obesity. Nelson's Textbook of Pediatrics, 1, 307-316.
13. Gottlieb M.G., Bodanese L.C., Leite L.E., Schwanke C.H., Piccoli J.C., da Rocha M.I., da Cruz IB. (2009). Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly. Metab Syndr Relat Disord, 7, 341-348.
14. Heo M., Leibel R.L., Fontaine K.R., Boyer B.B., Chung W.K., Koulu M., Karvonen M.K., Pesonen U., Rissanen A., Laakso M., Uusitupa M.I., Chagnon Y., Bouchard C., Donohoue P.A., Burns T.L., Shuldiner A.R., Silver K., Andersen R.E., Pedersen O., Echwald S., S0rensen T.I., Behn P., Permutt M.A., Jacobs K.B., Elston R.C., Hoffman D.J., Gropp E., Allison D.B. (2002). A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes, 26, 640-646. doi: 10.1038/sj.ijo.0801990.
15. Luvizotto R.A., Conde S.J., Oliveira M., Sibio M.D., Nagamati K. Jr., Nagamati C. (2012). Obesity and weight loss: the influence of thyroid hormone on adipokines. Thyroid Hormone, 396. doi: 10.5772/46179.
16. Mantzoros C.S., Ozata M., Negrao A.B., Suchard M.A., Ziotopoulou M., Caglayan S., Elashoff R.M., Cogswell R.J., Negro P., Liberty V., Wong M.L., Veldhuis J., Ozdemir I.C., Gold P.W., Flier J.S., Licinio J. (2001). Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab, 86, 3284-3291. doi: 10.1210/jcem.86.7.7644.
17. Marginean C.O., Marginean C., Voidăzan S., Melit L., Crauciuc A., Duicu C., Banescu C. (2016). Correlations between leptin gene polymorphisms 223 A/G, 1019 G/A, 492 G/C, 976 C/A, and anthropometrical and biochemical parameters in children with obesity. Medicine, 95 (12), e3115. doi: 10.1097/MD.0000000000003115.
18. Pyrzak B., Wisniewska A., Kucharska A., Wasik M., Demkow U. (2009). No association of LEPR Gln223Arg polymorphism with leptin, obesity or metabolic disturbances in children. Eur J Med Res, 14, 201-204.
19. Seufert J., Kieffer T.J., Leech C.A., Holz G.G., Moritz W., Ricordi C., Habener J.F. (1999). Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab, 84, 670-676.
20. Van der Vleuten G.M., Kluijtmans L.A., Hijmans A., Blom H.J., Stalenhoef A.F., de Graaf J. (2006). The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia. Int J Obes, 30, 892-898.
21. Van Rossum C.T., Hoebee B., van Baak M.A., Mars M., Saris W.H., Seidell J.C. (2003). Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res, 11, 377-386.
22. Yiannakouris N., Yannakoulia M., Melistas L., Chan J.L., Klimis-Zacas D., Mantzoros C.S. (2001). The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab, 86, 4434-4439
Review
For citations:
Ievleva K.D., Bairova T.A., Rychkova L.V., Sheneman E.A., Khramova E.E., Kolesnikova L.I. Metabolism and obesity: role of leptin receptor gene. Acta Biomedica Scientifica. 2017;2(5(1)):56-62. (In Russ.) https://doi.org/10.12737/article_59e85cb55584e4.51145791
Views:
1039
.png)
Email this article 
