Современные генетические и иммунологические аспекты патогенеза нарушения консолидации переломов (обзор литературы)

Цель данной статьи – провести анализ генетических и иммунологических механизмов развития нарушений консолидации переломов на современном научном этапе.

Материалы и методы. Поиск литературных источников проводился в открытых электронных базах данных научной литературы PubMed и eLIBRARY. Глубина поиска – 10 лет.

Результаты. В обзоре проведён анализ данных литературы о современном состоянии вопросов изучения молекулярно-генетических механизмов репаративной регенерации костной ткани, в том числе и в развитии нарушений консолидации переломов. Рассмотрены механизмы наиболее важных звеньев патогенеза, которые чаще всего приводят к различным нарушениям процессов репарации костной ткани на сегодняшний день.

Заключение. Процесс репарации костной ткани многогранен, и в его осуществлении принимает участие множество факторов, однако хотелось бы отметить, что ведущую роль в течении репаративной регенерации играет персонифицированный генетически запрограммированный ответ на данное патологическое состояние. Тем не менее, несмотря на неоспоримый прогресс современной медицины в изучении процессов восстановления кости после перелома, до настоящего момента остаётся множество «белых» пятен в данном вопросе, что диктует необходимость его дальнейшего всестороннего изучения с целью эффективного лечения пациентов с нарушением консолидации.

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