Роль апелина в функционировании репродуктивной системы
https://doi.org/10.29413/ABS.2019-4.3.1
Аннотация
Адипокин апелин посредством апелиновых рецепторов активирует широкий спектр сигнальных каскадов в клетках-мишенях и контролирует их рост, дифференцировку, апоптоз, энергетический обмен. В последние годы получены доказательства того, что мишенями апелина являются все компоненты гипоталамо-гипофизарно-гонадной оси, на что указывает экспрессия в них апелина и его рецептора. В гипоталамусе апелин модулирует активность меланокортиновой и грелиновой систем и опосредованно влияет на продукцию гонадолиберина. В яичниках он контролирует рост и созревание фолликулов, стимулирует ангиогенез, влияет на базальную и стимулированную другими факторами стероидогенную активность фолликулярных клеток. Изменения в апелиновой сигнальной системе тесно связаны с такими дисфункциями женской репродуктивной системы, как синдром поликистозных яичников, эндометриоз, рак. Информация о регуляции мужской репродуктивной системы апелином ограничивается исследованиями на животных, свидетельствующими о влиянии апелина на гипоталамические звенья гонадной оси. Участие апелина в регуляции репродуктивной системы открывает широкие возможности для разработки на его основе новых подходов для коррекции нарушений в этой системе и лечения бесплодия.
При поддержке: Работа выполнена при финансовой поддержке РФФИ и ДНТ (грант № 18-515-45004 ИНД_а) и частично госзадания АААА-А18-118012290427-7.
Об авторах
А. О. Шпаков
ФГБУН Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН
Россия
Россия
Шпаков Александр Олегович – доктор биологических наук, заведующий лабораторией молекулярной эндокринологии и нейрохимии
ID: 35231150500, РИНЦ SPIN-код: 6335-8311, Author ID: 87662
194223, г. Санкт-Петербург, пр. Тореза, 44
К. В. Деркач
ФГБУН Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН
Россия
Россия
Деркач Кира Викторовна – кандидат биологических наук, ведущий научный сотрудник лаборатории молекулярной эндокринологии и нейрохимии
SCOPUS ID: 6603743572; РИНЦ SPIN-код: 6925-1558; Author ID: 83183
194223, г. Санкт-Петербург, пр. Тореза, 44
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Рецензия
Для цитирования:
Шпаков А.О., Деркач К.В. Роль апелина в функционировании репродуктивной системы. Acta Biomedica Scientifica. 2019;4(3):7-17. https://doi.org/10.29413/ABS.2019-4.3.1
For citation:
Shpakov A.O., Derkach K.V. The Role of Apelin in the Functioning of the Reproductive System. Acta Biomedica Scientifica. 2019;4(3):7-17. (In Russ.) https://doi.org/10.29413/ABS.2019-4.3.1
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