Preview

Acta Biomedica Scientifica

Расширенный поиск

Роль апелина в функционировании репродуктивной системы

https://doi.org/10.29413/ABS.2019-4.3.1

Полный текст:

Аннотация

Адипокин апелин посредством апелиновых рецепторов активирует широкий спектр сигнальных каскадов в клетках-мишенях и контролирует их рост, дифференцировку, апоптоз, энергетический обмен. В последние годы получены доказательства того, что мишенями апелина являются все компоненты гипоталамо-гипофизарно-гонадной оси, на что указывает экспрессия в них апелина и его рецептора. В гипоталамусе апелин модулирует активность меланокортиновой и грелиновой систем и опосредованно влияет на продукцию гонадолиберина. В яичниках он контролирует рост и созревание фолликулов, стимулирует ангиогенез, влияет на базальную и стимулированную другими факторами стероидогенную активность фолликулярных клеток. Изменения в апелиновой сигнальной системе тесно связаны с такими дисфункциями женской репродуктивной системы, как синдром поликистозных яичников, эндометриоз, рак. Информация о регуляции мужской репродуктивной системы апелином ограничивается исследованиями на животных, свидетельствующими о влиянии апелина на гипоталамические звенья гонадной оси. Участие апелина в регуляции репродуктивной системы открывает широкие возможности для разработки на его основе новых подходов для коррекции нарушений в этой системе и лечения бесплодия.

Об авторах

А. О. Шпаков
ФГБУН Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН
Россия

Шпаков Александр Олегович – доктор биологических наук, заведующий лабораторией молекулярной эндокринологии и нейрохимии

ID: 35231150500, РИНЦ SPIN-код: 6335-8311, Author ID: 87662

194223, г. Санкт-Петербург, пр. Тореза, 44



К. В. Деркач
ФГБУН Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН
Россия

Деркач Кира Викторовна – кандидат биологических наук, ведущий научный сотрудник лаборатории молекулярной эндокринологии и нейрохимии

SCOPUS ID: 6603743572; РИНЦ SPIN-код: 6925-1558; Author ID: 83183

194223, г. Санкт-Петербург, пр. Тореза, 44



Список литературы

1. Шпаков А.О. Регуляция и молекулярные механизмы функционирования гипоталамо-гипофизарно-гонадной оси. СПб: Изд-во Политехнического университета; 2017

2. Roa J. Role of GnRH neurons and their neuronal afferents as key integrators between food intake regulatory signals and the control of reproduction. Int J Endocrinol. 2013; 2013: 518046. doi: 10.1155/2013/518046

3. Roumaud P, Martin L. Roles of leptin, adiponectin and resistin in the transcriptional regulation of steroidogenic genes contributing to decreased Leydig cells function in obesity. Horm Mol Biol Clin Invest. 2015; 24(1): 25-45. doi: 10.1515/hmbci-2015-0046

4. Shpakov AO, Ryzhov JuR, Bakhtyukov AA, Derkach KV. The regulation of the male hypothalamic-pituitary-gonadal axis and testosterone production by adipokines. In: Estrada M. (ed.). Advances in Testosterone Action. Rijeka, Croatia:IntechOpen; 2018: 25-57. doi: 10.5772/intechopen.76321

5. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem. Biophys. Res. Commun. 1998; 251 (2): 471–476. doi: 10.1006/bbrc.1998.9489

6. Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K, et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept. 2001; 99(2-3): 87-92. doi: 10.1016/s0167-0115(01)00236-1

7. Zhen EY, Higgs RE, Gutierrez JA. Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma. Anal Biochem. 2013; 442(1): 1-9. doi: 10.1016/j.ab.2013.07.006.

8. Wang W, McKinnie SMK, Farhan M, Paul M, McDonald T, McLean B, et al. Angiotensin-converting enzyme 2 metabolizes and partially inactivates pyr-apelin-13 and apelin-17: physiological effects in the cardiovascular system. Hypertension. 2016; 68(2): 365-377. doi: 10.1161/HYPERTENSIONAHA.115.06892

9. Gerbier R, Leroux V, Couvineau P, Alvear-Perez R, Maigret B, Llorens-Cortes C, et al. New structural insights into the apelin receptor: identification of key residues for apelin binding. FASEB J. 2015; 29(1): 314-322. doi: 10.1096/fj.14-256339

10. O’Carroll AM, Lolait SJ, Harris LE, Pope GR. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol. 2013; 219(1): R13-R35. doi: 10.1530/JOE-13-0227

11. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology. 2005; 146(4): 1764-1771. doi: 10.1210/en.2004-1427

12. De Falco M, De Luca L, Onori N, Cavallotti I, Artigiano F, Esposito V, et al. Apelin expression in normal human tissues. In Vivo. 2002; 16(5): 333-336.

13. Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrums. Biochim Biophys Acta. 1999; 1452(1): 25-35. doi: 10.1016/S0167-4889(99)00114-7

14. De Falco M, Fedele V, Russo T, Virgilio F, Sciarrillo R, Leone S, et al. Distribution of apelin, the endogenous ligand of the APJ receptor, in the lizard Podarcis sicula. J Mol Histol. 2004; 35(5): 521-527. doi: 10.1007/s10735-004-1247-1

15. Pitkin SL, Maguire JJ, Bonner TI, Davenport AP. International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function. Pharmacol Rev. 2010; 62: 331-342. doi: 10.1124/pr.110.002949

16. O’Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993; 136(1-2): 355-360. doi: 10.1016/0378-1119(93)90495-O

17. Masri B, Morin N, Pedebernade L, Knibiehler B, Audigier Y. The apelin receptor is coupled to Gi1 or Gi2 protein and is differentially desensitized by apelin fragments. J Biol Chem. 2006; 281(27): 18317-18326. doi: 10.1074/jbc.M600606200

18. Kurowska P, Barbe A, Różycka M, Chmielińska J, Dupont J, Rak A. Apelin in reproductive physiology and pathology of different species: a critical review. Int J Endocrinol. 2018; 2018: 9170480. doi: 10.1155/2018/9170480

19. Bai B, Tang J, Liu H, Chen J, Li Y, Song W. Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway. Acta Biochim Biophys Sinica. 2008; 40(4): 311-318. doi: 10.1111/j.1745-7270.2008.00403.x

20. Foussal C, Lairez O, Calise D, Pathak A, Guilbeau-Frugier C, Valet P, et al. Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett. 2010; 584(11): 2363-2370. doi: 10.1016/j.febslet.2010.04.025

21. Zeng XJ, Yu SP, Zhang L, Wei L. Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res. 2010; 316(11): 1773-1783. doi: 10.1016/j.yexcr.2010.02.005

22. Yang Y, Zhang XJ, Li LT, Cui HY, Zhang C, Zhu CH, et al. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. 2016; 75: 96-100. doi: 10.1016/j.peptides.2015.11.002

23. Yue P, Jin H, Xu S, Aillaud M, Deng AC, Azuma J, et al. Apelin decreases lipolysis via Gq, Gi, and AMPK-dependent mechanisms. Endocrinology. 2011; 152(1): 59-68. doi: 10.1210/en.2010-0576

24. O’Carroll AM, Lolait SJ, Howell GM. Transcriptional regulation of the rat apelin receptor gene: promoter cloning and identification of an Sp1 site necessary for promoter activity. J Mol Endocrinol. 2006; 36(1): 221-235. doi: 10.1677/jme.1.01927

25. Reaux A, Gallatz K, Palkovits M, Llorens-Cortes C. Distribution of apelin-synthesizing neurons in the adult rat brain. Neuroscience. 2002; 113(3): 653-662. doi: 10.1016/S0306-4522(02)00192-6

26. Reaux-Le Goazigo A, Bodineau L, De Mota N, Jeandel L, Chartrel N, Knauf C, et al. Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release. Am J Physiol. 2011; 301(5): E955-E966. doi: 10.1152/ajpendo.00090.2011

27. Saral S, Alkanat M, Sumer A, Canpolat S. Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats. Bratisl Lek Listy. 2018; 119(1): 47-53. doi: 10.4149/BLL_2018_010

28. Celik O, Celik N, Aydin S, Aygun BK, Haberal ET, Kuloglu T, et al. Ghrelin action on GnRH neurons and pituitary gonadotropes might be mediated by GnIH-GPR147 system. Horm Mol Biol Clin Investig. 2016; 25(2): 121-128. doi: 10.1515/hmbci-2015-0050

29. Ferrante C, Orlando G, Recinella L, Leone S, Chiavaroli A, Di Nisio C, et al. Central apelin 13 administration modulates hypothalamic control of feeding. J Biol Regul Homeost Agents. 2016; 30(3): 883-888.

30. Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, et al. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. Sci Rep. 2016; 6: 31849. doi: 10.1038/srep31849

31. Newson MJF, Pope GR, Roberts EM, Lolait SJ, O’Carroll AM. Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic-pituitary-adrenal axis response to acute stress. J Endocrinol. 2013; 216(1): 99-109. doi: 10.1530/JOE-12-0375

32. Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, et al. The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochem Biophys Res Commun. 2002; 291(5): 1208-1212. doi: 10.1006/bbrc.2002.6575

33. Bodineau L, Taveau C, Lê Quan Sang HH, Osterstock G, Queguiner I, Moos F, et al. Data supporting a new physiological role for brain apelin in the regulation of hypothalamic oxytocin neurons in lactating rats. Endocrinology. 2011; 152(9): 3492-3503. doi: 10.1210/en.2011-0206

34. Newson MJF, Roberts EM, Pope GR, Lolait SJ, O’Carroll AM. The effects of apelin on hypothalamic-pituitary-adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms. J Endocrinol. 2009; 202(1): 123-129. doi:10.1677/JOE-09-0093.

35. Roche J, Ramé C, Reverchon M, Mellouk N, Cornuau M, Guerif F, et al. Apelin (APLN) and apelin receptor (APLNR) in human ovary: expression, signaling, and regulation of steroidogenesis in primary human luteinized granulosa cells. Biol Reprod. 2016; 95(5): 104. doi: 10.1095/biolreprod.116.141754

36. Schilffarth S, Antoni B, Schams D, Meyer HH, Berisha B. The expression of apelin and its receptor APJ during different physiological stages in the bovine ovary. Int J Biol Sci. 2009; 5(4): 344-350. doi: 10.7150/ijbs.5.344.

37. Rak A, Drwal E, Rame C, Knapczyk-Stwora K, Słomczyńska M, Dupont J, et al. Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and different signaling pathways. Theriogenology. 2017; 96: 126-135. doi: 10.1016/j.theriogenology.2017.04.014.

38. Roche J, Ramé C, Reverchon M, Mellouk N, Rak A, Froment P, et al. Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells. Reproduction. 2017; 153(5): 589-603. doi: 10.1530/REP-16-0677

39. Shuang L, Jidong W, Hongjuan P, Zhenwei Y. Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells. Clin Exp Obst Gynecol. 2016; 43(3): 409-413.

40. Altinkaya SÖ, Nergiz S, Küçük M, Yüksel H. Apelin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome. Eur J Obst Gynecol Reprod Biol. 2014; 176: 168-172. doi: 10.1016/j.ejogrb.2014.02.022

41. Chang CY, Tsai YC, Lee CH, Chan TF, Wang SH, Su JH. Lower serum apelin levels in women with polycystic ovary syndrome. Fert Steril. 2011; 95(8): 2520-2523. doi: 10.1016/j.fertnstert.2011.04.044

42. Gören K, Sağsöz N, Noyan V, Yücel A, Cağlayan O, Bostancı MS. Plasma apelin levels in patients with polycystic ovary syndrome. J Turk Germ Gynecol Assoc. 2012; 13(1): 27-31. doi: 10.5152/jtgga.2011.74

43. Olszanecka-Glinianowicz M, Madej P, Nylec M, Owczarek A, Szanecki W, Skałba P, et al. Circulating apelin level in relation to nutritional status in polycystic ovary syndrome and its association with metabolic and hormonal disturbances. Clin Endocrinol. 2013; 79(2): 238-242. doi: 10.1111/cen.12120

44. Sun X, Wu X, Zhou Y, Yu X, Zhang W. Evaluation of apelin and insulin resistance in patients with PCOS and therapeutic effect of drospirenone-ethinylestradiol plus metformin. Med Sci Monitor. 2015; 21: 2547-2552. doi: 10.12659/MSM.894926

45. Ozkan ZS, Cilgin H, Simsek M, Cobanoglu B, Ilhan N. Investigation of apelin expression in endometriosis. J Reprod Infert. 2013; 14(2): 50–55.

46. Hoffmann M, Fiedor E, Ptak A. Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism. Toxicol Lett. 2017; 269: 15-22. doi: 10.1016/j.toxlet.2017.01.006

47. Picault FX, Chaves-Almagro C, Projetti F, Prats H, Masri B, Audigier Y. Tumour co-expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas. Eur J Cancer. 2014; 50(3): 663-674. doi: 10.1016/j.ejca.2013.11.017

48. Sandal S, Tekin S, Seker FB, Beytur A, Vardi N, Colak C, et al. The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats. Neurosci Lett. 2015; 602: 133-138. doi: 10.1016/j.neulet.2015.06.059

49. Tekin S, Erden Y, Sandal S, Etem Onalan E, Ozyalin F, Ozen H, et al. Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism. Arch Physiol Biochem. 2017; 123(1): 9-15. doi: 10.1080/13813455.2016.1211709

50. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003; 84(5): 1162-1172. doi: 10.1046/j.1471-4159.2003.01587.x

51. Pope GR, Roberts EM, Lolait SJ, O’Carroll AM. Central and peripheral apelin receptor distribution in the mouse: species differences with rat. Peptides. 2012; 33(1): 139-148. doi: 10.1016/j.peptides.2011.12.005


Для цитирования:


Шпаков А.О., Деркач К.В. Роль апелина в функционировании репродуктивной системы. Acta Biomedica Scientifica. 2019;4(3):7-17. https://doi.org/10.29413/ABS.2019-4.3.1

For citation:


Shpakov A.O., Derkach K.V. The Role of Apelin in the Functioning of the Reproductive System. Acta Biomedica Scientifica. 2019;4(3):7-17. (In Russ.) https://doi.org/10.29413/ABS.2019-4.3.1

Просмотров: 79


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2541-9420 (Print)
ISSN 2587-9596 (Online)