The formation of oxidative disorders in the population of Vladivostok under the influence of atmospheric microparticles
https://doi.org/10.12737/article_590823a47defa8.34126398
Abstract
We studied the response of trigger systems in healthy volunteers living in areas with different levels of air pollution. We determined that particles with the size of 800 microns and higher of relatively favorable region, particles with the size of less than 50 microns dominated in the air of the unfavorable area, among which there were the most hazardous to health amounts of microparticles - from 200 to 300 nm. Microparticles of unfavorable area causes the development of oxidative modifications of proteins and DNA contributing to the change of leukocyte potential energy. The increase in total antioxidant activity and response of thiol-disulfide system (the increase in thioredoxin, glutathione with a stable reductase level] maintains a balance of oxidation and antioxidant processes contributing to protection of the cellular and subcellular structures against considerable oxidative damage.
About the Authors
T. I. Vitkina
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration -Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
V. I. Yankova
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration -Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
T. A. Gvozdenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration -Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
Y. K. Denisenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration -Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
K. S. Golokhvast
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration -Research Institute of Medical Climatology and Rehabilitation Treatment; Far Eastern Federal University
Russian Federation
Russian Federation
References
1. Голохваст К.С. Атмосферные взвеси городов Дальнего Востока. - Владивосток: Изд-во ДВФУ, 2013. - 178 с
2. Дубинина Е.Е. Продукты метаболизма кислорода в функциональной активности клеток (жизнь и смерть, созидание и разрушение). Физиологические и клинико-биохимические процессы. - СПб.: Мед. Пресса, 2006. - 397 с
3. Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr., Whitsel L, Kaufman JD (2010). Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation, 121 (21), 2331-2378.
4. Faurschou A, Menne T, Johansen JD, Thyssen JP (2011). Metal allergen of the 21st century - a review on exposure, epidemiology and clinical manifestations of palladium allergy. Contact Dermatitis, 64 (4), 185-195.
5. Gehring U, Gruzieva O, Agius RM, Beelen R, Custovic A, Cyrys J, Eeftens M, Flexeder C, Fuertes E, Heinrich J, Hoffmann B, de Jongste JC, Kerkhof M, Klümper C, Korek M, Mölter A, Schultz ES, Simpson A, Sugiri D, Svartengren M, von Berg A, Wijga AH, Pershagen G, Brunekreef B (2013). Air pollution exposure and lung function in children: the ESCAPE project. Environmental Health Perspectives, 121 (11-12), 1357-1364.
6. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M, Anderson HR, Andrews KG, Aryee M, Atkinson C, Bacchus LJ, Bahalim AN, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell ML, Blore JD, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce NG, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett RT, Byers TE, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen JS, Cheng AT, Child JC, Cohen A, Colson KE, Cowie BC, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Des Jarlais DC, Devries K, Dherani M, Ding EL, Dorsey ER, Driscoll T, Edmond K, Ali SE, Engell RE, Erwin PJ, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane MM, Flaxman S, Fowkes FG, Freedman G, Freeman MK, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez HR, Hall W, Hoek HW, Hogan A, Hosgood HD 3rd, Hoy D, Hu H, Hubbell BJ, Hutchings SJ, Ibeanusi SE, Jacklyn GL, Jasrasaria R, Jonas JB, Kan H, Kanis JA, Kassebaum N, Kawakami N, Khang YH, Khatibzadeh S, Khoo JP, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher JL, Leigh J, Li Y, Lin JK, Lipshultz SE, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Mensah GA, Merriman TR, Micha R, Michaud C, Mishra V, Mohd Hanafiah K, Mokdad AA, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson PK, Nolla JM, Norman R, Olives C, Omer SB, Orchard J, Osborne R, Ostro B, Page A, Pandey KD, Parry CD, Passmore E, Patra J, Pearce N, Pelizzari PM, Petzold M et al. (2012). A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet, 380 (9859), 2224-2260.
7. Mahmood DFD, Abderrazak A, El Hadri K, Simmet T, Rouis M (2013). The thioredoxin system as a therapeutic target in human health and disease. Antioxidants and Redox Signaling, 19 (11), 1266-1303
Review
For citations:
Vitkina T.I., Yankova V.I., Gvozdenko T.A., Denisenko Y.K., Golokhvast K.S. The formation of oxidative disorders in the population of Vladivostok under the influence of atmospheric microparticles. Acta Biomedica Scientifica. 2016;1(3(2)):82-85. (In Russ.) https://doi.org/10.12737/article_590823a47defa8.34126398
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