Activity of lipid peroxidation processes in pregnant women with chronic viral hepatitis
https://doi.org/10.12737/article_590823a44563d3.22102831
Abstract
Viral hepatitis is a traditionally complexglobal problem for humans and is still far from being solved. For the last decade the incidence of chronic viral hepatitis in the Russian Federation has grown by 2.2 times. Many researchers point out aggravating mutual influence of viral hepatitis and рregnancy. The severity and development prognosis of liver diseases are closely interlinked with the functional state of oxidant and antioxidant systems of hepatocytes. Objective is to estimate the intensity rate of liрid peroxidation in рregnant women with chronic viral hepatitis. The material for biochemical studies was blood plasma. The content of the substrates for Ирid peroxidation - compounds with isolated double bonds and the products of lipid peroxidation processes (diene conjugates, ketodienes and conjugated trienes, thiobarbituric acid active products] was determined with spektrofluorofotometre "SHIMADZU-1501" (Japan]. We used modern spectrophotometric and statistical methods. It was found that there is increased activity of Ирid oxidation in patients with chronic viral hepatitis. Blood plasma levels of intermediate and final products of Ирid peroxidation are significantly elevated in patients with chronic viral hepatitis, compared to the control groups. Increase in plasma peroxidation products indicates the рresence of oxidative stress in patients with viral hepatitis. Study of parameters of liрid peroxidation is an informative method for the correction of the disease in рregnant women with chronic viral hepatitis.
About the Authors
O. A. Nikitina
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
M. A. Rashidova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
B. A. Fyodorov
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Колесникова Л.И., Даренская М.А., Долгих В.В., Шенин В.А., Осипова Е.В., Гребенкина Л.А., Долгих М.И., Мандзяк T.B. Особенности процессов перекисного окисления липидов-антиоксидантной защиты в различных этнических группах Восточной Сибири // Экология человека. - 2010. - № 2. -C. 26-29
2. Кудашкина E.A. Оригинальный подход к терапии при вирусных гепатитах В и С // Инновации в науке. - 2012. - № б. - C. 139-142
3. Ладыгин К.В., Болдырев A.B., Стативко O.A., Авдеева И.В. Эпидемиологические аспекты хронических гепатитов у ВИЧ-инфицированных женщин во время их беременности // Научные ведомости. Серия Медицина. Фармация. - 2014. - № 4 (25). - C. 5-10
4. Ренева Л.В., Волкова Л.В., Казьянин A.B. Поствакцинальный иммунитет к гепатиту у доноров плазмы // Вестник Уральской мед акад.наук. - 2013. - № 1. - C. 73-76
5. Шехтман М.М. Хронический гепатит и цирроз печени у беременных // Гинекология. - 2004. - № б. - C. 18-21
6. Ющук Н.Д., Знойко O.O., Дудина К.Р., Белый П.А. Проблема вирусного гепатита C в Российской Федерации // Терапевтический архив. - 2014. - T. 86, № 10. - C. 77-81
7. Bairova ТА, Kolesnikov SI, Kolesnikova LI, Pervushina OA, Darenskaya MA, Grebenkina LA (2014). Lipid peroxidation and mitochondrial superoxide dismutase-2 gene in adolescents with essential hypertension. Bulletin of Expermental Biology and Medicine, 158 (2), 181-184.
8. Chen CJ, Yang HI, Iloeje UH (2009). Hepatitis В virus DNA levels and outcomes in chronic hepatitis В Hepatitis В virus DNA levels and outcomes in chronic hepatitis В. Hepatology, 49, 72-84.
9. Dienstag JL (2008). Hepatitis В virus infection. The New Engl. J. Med., З59 (14), 1486-1500.
10. Kolesnikova L, Darenskaya M, Grebenkina L, Timofeeva Е, Leshenko O, Semenova N, Kurashova N, Vanteeva 0 (2014) Oxidative stress parameters in women with HIV and HIV/hepatitis В and/or С co-infection. Journal of AIDS and Clinical Research, 5 (її), 5-11.
11. Kolesnikova LI, Darenskaya MA, Semenova NV, Grebenkina LA, Suturina LV, Dolgikh MI, Gnusina SV (2015). Lipid peroxidation and antioxidant protection in girls with type і diabetes mellitus during reproductive system development. Medicina (Kaunas, Lithuania], 51 (2), 107-111.
12. Kolesnikova LI, Kolesnikov SI, Darenskaya MA, Grebenkina LA, Gnusina SV (2015). Antioxidant status of two ethnic groups’ adolescent girls with diabetes mellitus type I. Diabetes technology and therapeutics, 17 (і), 421-422.
13. Kolesnikova LI, Madaeva IM, Semenova NV, Vlasov BY, Grebenkina LA, Darenskaya MA, Dolgikh MI (2013). Antioxidant potential of the blood in men with obstructive sleep breathing disorders. Bulletin of Expeгіmental Biology and Medicine, 154 (6), 731-733.
Review
For citations:
Nikitina O.A., Rashidova M.A., Fyodorov B.A. Activity of lipid peroxidation processes in pregnant women with chronic viral hepatitis. Acta Biomedica Scientifica. 2016;1(3(2)):50-52. (In Russ.) https://doi.org/10.12737/article_590823a44563d3.22102831
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