Comparative assessment of prevalence of fibrinogen (-455)G>A gene polymorphism in teenagers from various populations of Eastern Siberia
Abstract
This study was performed to establish prevalence of alleles of polymorphism (-455)G>A of в-chain of fibrinogen gene in Russian and Buryat populations of Eastern Siberia. We used blood database of children and teenagers of Russian and Buryat nationality. Genotyping was carried out by a standard PCR method. Frequency of allele A in Russian population was 28,0 %, in Buryat population - 23,7 %. There were no statistically significant ethnic differences between these samples.
About the Authors
A. Y. Senkina
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
T. A. Bairova
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
S. I. Kolesnikov
RAS
Russian Federation
Russian Federation
O. V. Kalyuzhnaya
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Агапкина Ю.В. Полиморфные маркеры генов- кандидатов и генетическая предрасположенность к неблагоприятному исходу у больных, перенесших острый коронарный синдром: автореф. дис. ... канд. биол. наук. - М., 2010. - С. 13-15
2. Колесникова Л.И., Долгих В.В., Баирова Т.А., Бимбаев А.Б. Ген эндотелиальной синтазы окиси азота и эссенциальная артериальная гипертензия у подростков разных этнических групп, проживающих на территории Республики Бурятия // Бюл. СО РАМН. - 2009. - № 6. - С. 109-115
3. Щепотина Е.Г., Прасолова М.А., Иванов М.К. Новые наборы реагентов для выявления однонуклеотидных полиморфизмов генов фолатного цикла и системы свертывания крови // Новости «Вектор-Бест», информационный бюллетень. - 2013. - № 2. - C. 7
4. Fibrinogen Beta Chain/Gene Cards [Электронный ресурс]. - Режим доступа: http://www.genecards.org/ cgi-bin/carddisp.pl?gene=FGB&search=d436adeaeb56e 877a12226260dede661
5. Madjunkova S., Volk M., Peterlin B., Plaseska- Karanfilska D. Detection of thrombophilic mutations related to spontaneous abortions by a multiplex SNaPshot method // Genet. Test Mol. Biomarkers. - 2012. - N 16 (4). - P. 259-264.
6. Ng M.C., Wang Y., So W.Y., Cheng S. et al. Ethnic differences in the linkage disequilibrium and distribution of single-nucleotide polymorphisms in 35 candidate genes for cardiovascular diseases // Genomics. - 2004. - N 83. - P. 559-565.
7. Oszajca K., Wronski K., Janiszewska G., Bienkiewicz M. et al. Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen в chain genes with human abdominal aortic aneurysm // Experimental and Therapeutic Medicine. - 2012. - N 4 (3). - P. 514-518.
8. Rupert J.L., Devine D.V., Monsalve M.V., Hochachka P.W. Beta-fibrinogen allele frequencies in Peruvian Quechua, a highaltitude native population // Am. J. Phys. Anthropol. - 1999. - N 109. - P. 181-186.
Review
For citations:
Senkina A.Y., Bairova T.A., Kolesnikov S.I., Kalyuzhnaya O.V. Comparative assessment of prevalence of fibrinogen (-455)G>A gene polymorphism in teenagers from various populations of Eastern Siberia. Acta Biomedica Scientifica. 2014;(5):98-100. (In Russ.)
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