Study of apolipoprotein C3 S1/S2 (C3238G, rs5128) polymorphism in Caucasian population of Eastern Siberia
Abstract
The prevalence of genotypes and alleles of polymorphic marker S1 /S2 Apolipoprotein C3 in healthy adolescent Caucasians (Russians) living in Eastern Siberia was studied. Material for research was the DNA extracted from the venous blood; genotype was determined by PCR-RFLP for each sample. In the studied sample in 88.9 % of cases genotype S1/ S1 was detected, genotype S1/S2 was found in 8.6 %, S2/S2 - in 2.5 %. The share of S2 allele was 6.8 %, which is not significantly different from the previously studied Caucasoid populations.
About the Authors
O. V. Kalyuzhnaya
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
T. A. Bairova
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
V. V. Dolgikh
Scientific Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
S. I. Kolesnikov
RAS
Russian Federation
Russian Federation
References
1. Климов А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения; 3-е изд. - СПб.: Питер Ком, 1999. - 512 с
2. Творогова М.Г. Аполипопротеины - свойства, методы определения, клиническая значимость // Лабораторная медицина. - 2005. - № 7. - С. 29-37
3. Bandegi A.R., Firoozrai M., Akbari E.M.R., Kokhaei P. SstI Polymorphism of the Apolipoprotein CIII Gene in Iranian Hyperlipidemic Patients: A Study in Semnan Province // Iranian J. Basic Med. Sciences. - 2011. - Vol. 14, N 6. - P. 506-513.
4. Chhabra S., Agarwal D.P., Vasisht S., Luthra K. et al. Study of Apolipoprotein С3 Sst1 polymorphism in healthy volunteers from Northern India // Ind. J. Clin. Biochem. - 2003. - Vol. 18, N 2. - P. 34-38.
5. Chhabra S., Narang R., Krishnan L.R., Vasisht S. et al. Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians // BMC Genetics. - 2002. - Vol. 3, N 9.
6. Ghattas M., Badawy H., Mesbah N., Abo-Elmatty D. Apolipoprotein CIII 3238C/G Gene polymorphism influences oxidized low-density lipoprotein with a risk of essential hypertension // J. Biochem. Pharmacol. Res. - 2013. - Vol. 1, N 3. - P. 143-147.
7. Groenendijk M., Cantor R.M., de Bruin T.W., Dallinga-Thie G.M. The apoAI-CIII-AIV gene cluster // Atherosclerosis. - 2001. - N 157. - P. 1-11.
8. Hoffer M.J.V., Sijbrands E.J.G., de Man F.H.A.F., Havekes L.M. et al. Increased risk for endogenous hypertriglyceridaemia isassociated with an apolipoprotein C3 haplotype specified by the SstI polymorphism // Eur. J. Clin. Invest. - 1998. - N 28. - P. 807-812.
9. Hong S.H., Park W.H., Lee C.C., Hong J.H. et al. Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects // Clin. Chem. - 1997. - N 43. - P. 13-17.
10. Liu H.K., Li X.F., Zhang S.Z., Ren Y. et al. Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population // Acta Genetica Sinica. - 2005. - Vol. 32, N 1. - P. 11-18.
11. Olivieri O., Stranieri C., Bassi A., Zaia B. [et al.]. ApoC-III gene polymorphisms and risk of coronary artery disease // J. Lipid Res. 2002. № 43. P. 1450-1457.
12. Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C. et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing // Science. - 2001. - N 294. - P. 169-173.
13. Russo G.T., Meigs J.B., Cupples L.A., Demissie S. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study // Atherosclerosis. - 2001. - N 158. - P. 173-181.
Review
For citations:
Kalyuzhnaya O.V., Bairova T.A., Dolgikh V.V., Kolesnikov S.I. Study of apolipoprotein C3 S1/S2 (C3238G, rs5128) polymorphism in Caucasian population of Eastern Siberia. Acta Biomedica Scientifica. 2014;(5):95-97. (In Russ.)
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