actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-1822Research ArticleГЕНОМИКА И ПРОТЕОМИКАGENOMICS AND PROTEOMICSИзучение полиморфизма S1/S2 (C3238G, rs5128) аполипопротеина C3 в европейской популяции Восточной СибириStudy of apolipoprotein C3 S1/S2 (C3238G, rs5128) polymorphism in Caucasian population of Eastern SiberiaКалюжнаяО. В.KalyuzhnayaO. V.kaluzhnayaO@yandex.ruБаироваТ. А.BairovaT. A.noemail@neicon.ruДолгихВ. В.DolgikhV. V.noemail@neicon.ruКолесниковС. И.KolesnikovS. I.noemail@neicon.ruНаучный центр проблем здоровья семьи и репродукции человекаScientific Center for Family Health and Human Reproduction ProblemsРАНRAS201428092014059597Copyright © Калюжная О.В., Баирова Т.А., Долгих В.В., Колесников С.И., 20142014Калюжная О.В., Баирова Т.А., Долгих В.В., Колесников С.И.Kalyuzhnaya O.V., Bairova T.A., Dolgikh V.V., Kolesnikov S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/1822

Изучена распространенность генотипов и аллелей полиморфного маркера S1/S2 гена аполипопротеина С3 (C3238G, rs5128) в группе здоровых подростков европеоидной расы (русских) проживающих на территории Восточной Сибири. Материалом для исследования являлась ДНК выделенная из венозной крови, генотип для каждого образца определяли методом ПЦР-ПДРФ. В исследованной выборке в 88,9 % случаев встречался генотип S1/S1, генотип S1/S2 - в 8,6 %, S2/S2 - в 2,5 %. Доля аллеля S2 составила 6,8 %, что достоверно не отличается от ранее исследованных европеоидных популяций.

The prevalence of genotypes and alleles of polymorphic marker S1 /S2 Apolipoprotein C3 in healthy adolescent Caucasians (Russians) living in Eastern Siberia was studied. Material for research was the DNA extracted from the venous blood; genotype was determined by PCR-RFLP for each sample. In the studied sample in 88.9 % of cases genotype S1/ S1 was detected, genotype S1/S2 was found in 8.6 %, S2/S2 - in 2.5 %. The share of S2 allele was 6.8 %, which is not significantly different from the previously studied Caucasoid populations.

аполипопротеин С3аллельгенотипS1/S2apolipoprotein C3S1/S2allelegenotypeReferencesКлимов А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения; 3-е изд. - СПб.: Питер Ком, 1999. - 512 сКлимов А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения; 3-е изд. - СПб.: Питер Ком, 1999. - 512 сТворогова М.Г. Аполипопротеины - свойства, методы определения, клиническая значимость // Лабораторная медицина. - 2005. - № 7. - С. 29-37Творогова М.Г. Аполипопротеины - свойства, методы определения, клиническая значимость // Лабораторная медицина. - 2005. - № 7. - С. 29-37Bandegi A.R., Firoozrai M., Akbari E.M.R., Kokhaei P. SstI Polymorphism of the Apolipoprotein CIII Gene in Iranian Hyperlipidemic Patients: A Study in Semnan Province // Iranian J. Basic Med. Sciences. - 2011. - Vol. 14, N 6. - P. 506-513.Bandegi A.R., Firoozrai M., Akbari E.M.R., Kokhaei P. SstI Polymorphism of the Apolipoprotein CIII Gene in Iranian Hyperlipidemic Patients: A Study in Semnan Province // Iranian J. Basic Med. Sciences. - 2011. - Vol. 14, N 6. - P. 506-513.Chhabra S., Agarwal D.P., Vasisht S., Luthra K. et al. Study of Apolipoprotein С3 Sst1 polymorphism in healthy volunteers from Northern India // Ind. J. Clin. Biochem. - 2003. - Vol. 18, N 2. - P. 34-38.Chhabra S., Agarwal D.P., Vasisht S., Luthra K. et al. Study of Apolipoprotein С3 Sst1 polymorphism in healthy volunteers from Northern India // Ind. J. Clin. Biochem. - 2003. - Vol. 18, N 2. - P. 34-38.Chhabra S., Narang R., Krishnan L.R., Vasisht S. et al. Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians // BMC Genetics. - 2002. - Vol. 3, N 9.Chhabra S., Narang R., Krishnan L.R., Vasisht S. et al. Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians // BMC Genetics. - 2002. - Vol. 3, N 9.Ghattas M., Badawy H., Mesbah N., Abo-Elmatty D. Apolipoprotein CIII 3238C/G Gene polymorphism influences oxidized low-density lipoprotein with a risk of essential hypertension // J. Biochem. Pharmacol. Res. - 2013. - Vol. 1, N 3. - P. 143-147.Ghattas M., Badawy H., Mesbah N., Abo-Elmatty D. Apolipoprotein CIII 3238C/G Gene polymorphism influences oxidized low-density lipoprotein with a risk of essential hypertension // J. Biochem. Pharmacol. Res. - 2013. - Vol. 1, N 3. - P. 143-147.Groenendijk M., Cantor R.M., de Bruin T.W., Dallinga-Thie G.M. The apoAI-CIII-AIV gene cluster // Atherosclerosis. - 2001. - N 157. - P. 1-11.Groenendijk M., Cantor R.M., de Bruin T.W., Dallinga-Thie G.M. The apoAI-CIII-AIV gene cluster // Atherosclerosis. - 2001. - N 157. - P. 1-11.Hoffer M.J.V., Sijbrands E.J.G., de Man F.H.A.F., Havekes L.M. et al. Increased risk for endogenous hypertriglyceridaemia isassociated with an apolipoprotein C3 haplotype specified by the SstI polymorphism // Eur. J. Clin. Invest. - 1998. - N 28. - P. 807-812.Hoffer M.J.V., Sijbrands E.J.G., de Man F.H.A.F., Havekes L.M. et al. Increased risk for endogenous hypertriglyceridaemia isassociated with an apolipoprotein C3 haplotype specified by the SstI polymorphism // Eur. J. Clin. Invest. - 1998. - N 28. - P. 807-812.Hong S.H., Park W.H., Lee C.C., Hong J.H. et al. Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects // Clin. Chem. - 1997. - N 43. - P. 13-17.Hong S.H., Park W.H., Lee C.C., Hong J.H. et al. Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects // Clin. Chem. - 1997. - N 43. - P. 13-17.Liu H.K., Li X.F., Zhang S.Z., Ren Y. et al. Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population // Acta Genetica Sinica. - 2005. - Vol. 32, N 1. - P. 11-18.Liu H.K., Li X.F., Zhang S.Z., Ren Y. et al. Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population // Acta Genetica Sinica. - 2005. - Vol. 32, N 1. - P. 11-18.Olivieri O., Stranieri C., Bassi A., Zaia B. [et al.]. ApoC-III gene polymorphisms and risk of coronary artery disease // J. Lipid Res. 2002. № 43. P. 1450-1457.Olivieri O., Stranieri C., Bassi A., Zaia B. [et al.]. ApoC-III gene polymorphisms and risk of coronary artery disease // J. Lipid Res. 2002. № 43. P. 1450-1457.Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C. et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing // Science. - 2001. - N 294. - P. 169-173.Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C. et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing // Science. - 2001. - N 294. - P. 169-173.Russo G.T., Meigs J.B., Cupples L.A., Demissie S. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study // Atherosclerosis. - 2001. - N 158. - P. 173-181.Russo G.T., Meigs J.B., Cupples L.A., Demissie S. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study // Atherosclerosis. - 2001. - N 158. - P. 173-181.

The authors declare that there are no conflicts of interest present.