Preview

Acta Biomedica Scientifica

Advanced search

CATAMNESIS OF CHILDREN WITH COMPROMISED HEREDITARY BACKGROUND OF THROMBOSIS

Abstract

The research is dedicated to the study of characteristics of health of children, whose relatives of 1st and 2nd lines suffered thrombosis of vessels of different caliber and localizations before the age of 50. We examined 28 children of 13,5 ± 4,9 years. The results showed that 43 % of children suffered hypoxia in utero caused by chronic fetoplacental insufficiency. Up to 64 % of children have abnormalities in the state of their health, causing the risk of thrombosis in the future: hypertension, obesity, cardiac valve disease. 7 children have already suffered thrombosis in vessels of different caliber and localization by the moment of the study. The combination of inherited genes was correlated with the development of thrombosis in children (r = 0,24, p = 0,05).

About the Authors

L. V. Zhdanova
Buryat Branch of Scientific Center of Family Health and Human Reproduction Problems SB RAMS; Buryat State University
Russian Federation


L. I. Patrushev
Institute of Bioorganic Chemistry named after M.M. Shemyakin and Yu.A. Ovchinnikov
Russian Federation


V. V. Dolgikh
Scientific Center of Family Health and Human Reproduction Problems
Russian Federation


A. B. Bimbaev
Buryat Branch of Scientific Center of Family Health and Human Reproduction Problems SB RAMS; Buryat State University
Russian Federation


References

1. Жданова Л.В., Щербакова М.Ю., Решетняк Т.М. Встречаемость антител к фосфолипидам и генетических тромбофилий у детей без системных заболеваний соединительной ткани // Бюл. ВСНЦ СО РАМН. - 2009. - № 2. - С. 50-54. Zhdanova L.V., Shcherbakova M.Yu. Reshetnyak T.M. Occurrence of antibodies to phospholipids and of hereditary trombophilia in children without systemic connective tissue diseases // Bull. ESSC SB RAMS. - 2009. - N 2. - P. 50-54. (in Russian)

2. Calhoon M.J., Ross C.N., Pounder E. et al. High prevalence of thrombophilic traits in children with family history of thromboembolism // J. Pediatr. - 2010. -Vol. 157 (3). - P. 485-489.

3. Favaloro E.J., Mohammed S., Pati N. et al. clinical audit of congenital thrombophilia investigation in tertiary practice // Pathology. - 2011. - Vol. 43 (3). -P. 266-272.

4. Holzhauer S., Goldenberg N.A., Junker R. et al. Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study // Blood. - 2012. - Vol. 120 (7). - P. 1510-1515.

5. Wright J.M., Watts R.G. Venous thromboembolism in pediatric patients: epidemiologic data from a pediatric tertiary care center in Alabama // J. Pediatr. Hematol. Oncol. - 2011. - Vol. 33 (4). - P. 261-264.


Review

For citations:


Zhdanova L.V., Patrushev L.I., Dolgikh V.V., Bimbaev A.B. CATAMNESIS OF CHILDREN WITH COMPROMISED HEREDITARY BACKGROUND OF THROMBOSIS. Acta Biomedica Scientifica. 2014;(2):20-23. (In Russ.)

Views: 395


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2541-9420 (Print)
ISSN 2587-9596 (Online)