Effect of single intake of exogenous hepatocytes growth inducer on the indices of non-specific resistance under conditions of postresection liver injury
https://doi.org/10.12737/21485
Abstract
HGF is one of the factors taking part in regeneration and recovery of liver after injury. The article is dedicated to the study of influence of single HGF intake on the indices of non-specific immune response in rats after 70% liver resection in the early postoperative period. Research was conducted on 42 six-months white male Wistar rats of 250-300 g. It was revealed that level of segmentonuclear neutrophils and lymphocytes in the group with HGF intake stand at normal level on the 2nd day and normalizes to the 11th day that testifies to the decrease of inflammatory response. Increased level of leukocytes and monocytes is registered in the group with HGF intake. Also integrity of non-specific resistance in the early postoperative period on the 2nd day is registered. Suppression of phagocytosis indices with preservation of functional activity of phagocytes was registered to the 11th day.
About the Authors
S. A. Lepekhova
Irkutsk Scientific Center of Surgery and Traumatology; Irkutsk Scientific Center SB RAS; Irkutsk State Medical University
Russian Federation
Russian Federation
L. V. Zaritskaya
Irkutsk Scientific Center of Surgery and Traumatology; Irkutsk State Medical Academy of Continuing Education
Russian Federation
Russian Federation
E. V. Batunova
Irkutsk State Medical Academy of Continuing Education
Russian Federation
Russian Federation
K. A. Apartsin
Irkutsk Scientific Center SB RAS; Irkutsk State Medical University
Russian Federation
Russian Federation
O. N. Postovaya
Irkutsk State Medical Academy of Continuing Education
Russian Federation
Russian Federation
I. S. Kurganskiy
Irkutsk Scientific Center of Surgery and Traumatolog
Russian Federation
Russian Federation
M. V. Prokopjev
Irkutsk Scientific Center of Surgery and Traumatolog
Russian Federation
Russian Federation
E. V. Koval
Irkutsk Scientific Center of Surgery and Traumatolog
Russian Federation
Russian Federation
P. S. Makoshina
Irkutsk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Lepekhova S.A., Zaritskaya L.V., Batunova E.V., Apartsin K.A., Postovaya O.N., Kurganskiy I.S., Prokopjev M.V., Koval E.V., Makoshina P.S. Effect of single intake of exogenous hepatocytes growth inducer on the indices of non-specific resistance under conditions of postresection liver injury. Acta Biomedica Scientifica. 2016;1(1):49-55. (In Russ.) https://doi.org/10.12737/21485
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