The effect of environmental factors on the immune-metabolic status of people living in industrial areas of Primorsky region

Abstract

The estimation of the total effect of the environment on immune-metabolic parameters of people living in industrial areas of Primorsky region was conducted. The study involved 1128 healthy people living in the Primorsky region for at least 10 years. Integrated exposure index (HE) that takes into account the gradient of "response of the body" to the combined effects of multiple environmental factors (climatic, technological, socioeconomic, etc.) was developed. With use of gradient approach in Primorye 4 categories of areas were identified: the relatively favorable (IIE > 0,4), moderate (IIE = 0,3-0,4), relatively unfavorable (IIE = 0,2-0,3) and unfavorable environment (IIE < 0,2). In the second phase of the study database of normalized immune-metabolic parameters of healthy people living in the industrial centers of the Primorsky region was established. The valuation was carried out relatively to the values of the studied parameters of healthy individuals living in the mostfavorable conditions (IIE > 0,4). With the use of cluster analysis the classification of objects method К-means was performed, which revealed three immune-metabolic phenotypes. Compensated phenotype corresponds to the first phase of the adaptation of the organism - the activation parameters. Increased exposure leads to the formation of subcompensated phenotype, and the destruction of the body of the adaptation fund - to the formation of decompensated phenotype. The distribution of the proportion of healthy individuals with selected phenotypes in the population living in the areas with different environmental pressure shows the following dependencies: compensated and subcompensated phenotypes prevalent in areas with better living conditions, the percentage of decompensated phenotype increased environmental degradation. In areas where environmental load exceeds the capability to adapt the body subcompensated and decompensated phenotypes prevail. Violations identified unfavorable combination of endogenous and exogenous risk factors may be the basis for the formation of disease.