The development of the posterity of male and female outbred rats exposed to sublimate
Abstract
Mercury has gonadotropic and mutagenic effects on the Mammalia organism. This fact indicates the possibility of appearance of the mercury exposure effects on the offspring whose parents were exposed to this toxicant. The sublimate effects on the development of the first generation offspring from male and female outbred rats exposed to this substance were studied. Sublimate solution. (0,05 mg of mercury for 100 g of animal's body weight) was injected subcutaneously to outbred rats during 6 weeks. After ending of the injections these rats were mated with intact rats for getting the posterity. The examination of albino rats posterity had two stages. The first stage was to study the development of sensor-motional reactions on the first and. the tenth days of life. The second stage included the research of zoosocial behavior of sexually mature rats and. their activity in open field. Also the posterity was weighted for estimation of physical development. Obtained, materials of the researches were elaborated with use of methods of nonparametric statistics (Mann — Whitney U-criteria). At the analysis of the results of the experiment we revealed statistically significant differences in body weight and. motive activity of animals of experimental group in comparison with control group. Decrease of body weight in posterity of experimental male rats was revealed and. there were no differences in maturation of sensor-motional reflexes in their first days of life. Increase of body weight and motional activity was revealed in posterity of female rats with sublimate intoxication in comparison with control values. Changes of body weight and. behavior were registered in sexually mature posterity. Increase of body weight in comparison with control group was registered at the weighing of experimental animals. Depression of motive, position-finding, research and zoosocial activity was revealed in posterity of experimental male rats. Depression of motive, position-finding and. research activity was revealed in male posterity of experimental female rats and. strengthening of position-finding and. research activity was revealed in their female posterity.
About the Author
E. A. Kapustina
Ангарский филиал ФГБУ «ВСНЦ ЭЧ» СО РАМН - НИИ медицины труда и экологии человека
Russian Federation
Russian Federation
References
1. Арефьева А.С., Барыгина В.В., Зацепина О.В. Современные представления о влиянии ртути на клеточном и системном уровне // Экология человека. - 2010. - № 8. - С. 35-41.
2. Безгодов И.В. Оценка ртутной опасности на предприятиях химической промышленности Иркутской области // Бюл. ВСНЦ СО РАМН. -2005. - № 2 (40). - С. 70-74.
3. Буреш Я., Бурешова О., Хьюстон Д.П. Методики и основные эксперименты по изучению мозга и поведения. - М.: Высшая школа, 1991. - 399 с.
4. Ефимова Н.В. Проблемы, связанные с загрязнением ртутью объектов окружающей среды // Бюл. ВСНЦ СО РАМН. - 2005. - № 1 (39). -С. 127-133.
5. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. - М.: Медиа Сфера, 2002. - 312 с.
6. Токсикологическая химия. Метаболизм и анализ токсикантов: учебное пособие / Под ред. проф. Н.И. Калетиной. - М.: ГЭОТАР-Медиа, 2008. - 1016 с.
7. Anwar W.A., Gabal M.S. Cytogenetic study in workers occupationally exposed to mercury fulminate // Mutagenesis. - 1991. - N 6. - P. 189-192.
8. Bonacker D. Genotoxicity of inorganic mercury salts based on disturbed microtubule function // Arch. Toxicol. - 2004. - N 68, Vol. 10. - P. 575-583.
9. Howard W. Induction of chromosome changes by metal compounds in cultured CHO cells // Toxicological Letters. - 1991. - N 56. - P. 178-186.
10. Lamperti A.A., Printz R.H. Localization, accumulation and toxic effects of mercuric chloride on the reproductive axis of the female hamster // Biol. Reprod. - 1974. - N 11. - P. 180-186.
11. Schurz F., Saber-Vilar M., Fink-Crenmels J. Mutagenicity of me.rcury chloride and mechanisms of cellular defence: the role of metal-binding proteins // Mutagenesis. - 2000. - N 6, Vol. 15. - P 525-530.
12. Boujbina M.A. Testicular in mercuric chloride treated rats association with oxidative stress // Reproductive toxicology. - 2009. - N 28, Vol. 1. -P. 81-89.
13. Rudge C.V. The placenta as a barrier for toxic and essential elements in paired maternal and cord blood samples of South African delivering women // J. Environ. Monit. - 2009. - N 11, Vol. 7. -Р. 1322-1330.
14. Wong E.W., Cheng C.Y. Impact of environmental toxicants on male reproductive dysfunction // Trends in Pharmacological Sciences. - 2011. -N 32, Vol. 5. - P. 290-299.
15. Zasukhina A.D. Mutagenic effect of thallium and mercury salts on rodent cells with different repair activities // Mutation Research. - 1983. - N 124. -P. 163-173.
Review
For citations:
Kapustina E.A. The development of the posterity of male and female outbred rats exposed to sublimate. Acta Biomedica Scientifica. 2013;(1):102-105. (In Russ.)
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