EFFECTIVE MANAGEMENT OF PULMONARY TUBERCULOSIS COMPLICATED WITH MYCOBACTERIAL DRUG RESISTANCE IN THE REPUBLIC OF BURYATIA

Abstract

We present the results of treatment of patients with primary multidrug resistant pulmonary tuberculosis (MDR PT) (main group) and with acquiring MDR PT (comparison group) in Republic of Buryatia. We used the indexes for estimation of the treatment results according to the international standard. Index of sputum clean negativations is higher in main group - 77,8 %, in comparison, group - 44,4 %. The rate of negative sputum, in main group was 78 %, in comparison group - 41,9 % (р < 0,01). Increasing of drug resistance to reserved, medication up to MDR were often in the 2^nd group (21/10,3 %). Tolerability to reserved, medication, in the 1^st group was better than in the 2^nd group (28 % and. 43,4 % correspondingly, р < 0,05). In 24 months there were 26 % recovered patients in the 1^st group and. 10,8 % in the 2^nd group (р<0, 01). Negative treatment result was observed only in the 1^st group (n = 5, 2,5 %). Treatment was interrupted in 18 % of the 1^st group of patients and. in 28,1 % of the 2^nd group of patients. There were 21 patients died in the 2^nd group (10,3 %). We suppose that in the cases of tuberculosis the treatment results could be improved by the early diagnose of MDR and. balanced anti-tuberculosis treatment.