TO THE POSSIBILITY OF REVEALING OF SIDE EFFECTS OF METRONIDAZOLE (0,5% INFUSION SOLUTION, 100 ML) IN EXPERIMENT
Abstract
An. experimental research, of infusion solution of Metronidazole at single and repeated administration to the animals (rabbits) was carried out. Distinct signs of toxicity of the researched pattern. in the dose that is ten times higher than maximum, daily dose were determined. It concerns statistically reliably changed hematologic, biochemical and. electrophysiological indices that are typical for Metronidazole in particular. Only the fact of increase of content of creatinine in blood serum in 2 weeks after the administration, of the preparation should be registered but in this case it can be the signal to stop further administration, of the preparation.
About the Authors
A. G. Yushkov
Scientific Center of Reconstructive and Restorative Surgery SB RAMS
Russian Federation
Russian Federation
N. A. Shulgina
Scientific Institute of Biophysics of Angarsk State Technical Academy
Russian Federation
Russian Federation
A. A. Gushchina
Scientific Institute of Biophysics of Angarsk State Technical Academy
Russian Federation
Russian Federation
G. G. Yushkov
Scientific Institute of Biophysics of Angarsk State Technical Academy
Russian Federation
Russian Federation
M. M. Rasulov
Moscow City Pedagogical University
Russian Federation
Russian Federation
V. V. Benemanskiy
Scientific Institute of Biophysics of Angarsk State Technical Academy
Russian Federation
Russian Federation
M. M. Boon
Scientific Institute of Biophysics of Angarsk State Technical Academy
Russian Federation
Russian Federation
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Review
For citations:
Yushkov A.G., Shulgina N.A., Gushchina A.A., Yushkov G.G., Rasulov M.M., Benemanskiy V.V., Boon M.M. TO THE POSSIBILITY OF REVEALING OF SIDE EFFECTS OF METRONIDAZOLE (0,5% INFUSION SOLUTION, 100 ML) IN EXPERIMENT. Acta Biomedica Scientifica. 2012;(4(2)):216-219. (In Russ.)
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