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DYSFUNCTION OF PEROXISOMES AS ONE OF POSSIBLE CAUSES OF DEVELOPMENT OF MULTIPLE ORGAN DYSFUNCTION SYNDROME

Abstract

The article presents the results of researches of fatty aldehydes and total cholesterol of blood plasma of patients with multiple organ dysfunction syndrome. On the basis of determined significant decrease of analyzed compounds level we concluded about possibility of peroxysomal dysfunction at this syndrome. The article cites literary data that indicate significant role of peroxisomes in the formation of severe metabolic disturbances and. the development of inflammatory reactions.

About the Authors

A. N. Osipenko
Mogilev State University named after A.A. Kuleshov
Russian Federation


A. V. Marochkov
Mogilev Regional Hospital
Russian Federation


N. V. Akulich
Mogilev State University named after A.A. Kuleshov
Russian Federation


References

1. Зиновик А.В., Гусина Н.Б. Нарушение биогенеза пероксисом (клиника, диагностика, лечение). - Минск: ГУ РНПЦ «Мать и дитя», 2011. - 30 с.

2. Кейтс М. Техника липидологии. Выделение, анализ и идентификация липидов. - М.: Мир, 1975. - 322 с.

3. Лейдерман И.Н. Синдром полиорганной недостаточности (ПОН). Метаболические основы (Ч. 1) // Вестник интенсивной терапии. -1999. - № 2. - С. 8-13.

4. Медик В.А., Токмачев М.С., Фишман Б.Б. Статистика в медицине и биологии: руководство: в 2-х т. - М.: Медицина, 2000. - Т. 1: Теоретическая статистика. - 412 с.

5. Саенко В.Ф., Десятерик В.И., Перцева Т.А., Шаповалюк В.В. Сепсис и полиорганная недостаточность. - Кривой Рог: Минерал, 2005. - 466 с.

6. Титов В.Н., Лисицын Д.М. Жирные кислоты. Физическая химия, биология и медицина. - М. -Тверь: ООО «Издательство «Триада», 2006. -672 с.

7. Falagas M.E., Makris G.C., Matthaiou D.K., Rafailidis P.I. Statins for infection and sepsis: a systematic review of the clinical evidence // J. Antimicrob. Chemother. - 2008. - Vol. 61, N 4. - P. 774 - 785.

8. Farooqui A.A., Rapoport S.I., Horrocks L.A. Membrane phospholipid alterations in Alzheimer's disease: deficiency of ethanolamine plasmalogens // J. Neurochem. Res. - 1997. - Vol. 22, N 4. -P. 523 - 527.

9. Habor A. Peroxisome proliferator activated receptors // Farmacia. - 2010. - Vol. 58, N 5. -P. 13 - 20.

10. Khan M., Singh J., Singh I. Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin // J. Neurochem. - 2008. -Vol. 106, N 4. - P. 1766 - 1779.

11. Kovacs W.J., Shackelford J.E., Tape K.N. et al. Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model // J. Mol. Cell. Biol. - 2004. - Vol. 24, N 1. - P. 1 - 13.

12. Lebovitz H.E., Banerji M.A. Insulin resistance and its treatment by thiazolidinediones // Recent Prog. Horm. Res. - 2001. - Vol. 56. - P. 265 - 294.

13. Mandel H., Getsis M., Rosenblat M. et al. Reduced cellular cholesterol content in peroxisome-deficient fibroblasts is associated with impaired uptake of the patient's low density lipoprotein and with reduced cholesterol synthesis // J. Lipid Res. -1995. - Vol. 36, N 6. - P. 1385 - 1391.

14. Paumelle R., Staels B. Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins // J. Circulation Res. - 2007. - Vol. 100. -P. 1394-1395.

15. Wanders R.J.A., Waterham H.R. Biochemistry of mammalian peroxisomes revisited // J. Ann. Rev. Biochem. - 2006. - Vol. 75. - P. 295 - 332.


Review

For citations:


Osipenko A.N., Marochkov A.V., Akulich N.V. DYSFUNCTION OF PEROXISOMES AS ONE OF POSSIBLE CAUSES OF DEVELOPMENT OF MULTIPLE ORGAN DYSFUNCTION SYNDROME. Acta Biomedica Scientifica. 2012;(4(2)):96-100. (In Russ.)

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ISSN 2587-9596 (Online)