LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
Abstract
Syngeneic splenocyte transplantation leads to lymphopenia development in intact mice owing to decreased proliferative activity of bone marrow hematopoietic progenitor cells. In the mice with induced chronic graft-versus-host disease (cGVHD) transfer of syngeneic lymphocytes has little or no effect on the level of already existing lymphopenia, but increases its duration. These results are in close agreement with the received evidences that transfer of syngeneic cells increases frequency of autoimmune glomerulonephritis at cGVHD. Thus, results of research speak in favor of conclusion that lymphopenia and initiated by it homeostatic proliferation play a pathogenetic role in the development of autoimmune reactions at cGVHD.
About the Authors
E. V. Goiman
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
V. O. Tkachev
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
O. T. Kudayeva
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
O. P. Kolesnikova
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
V. A. Kozlov
Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
References
1. Козлов В.А., Кудаева О.Т., Колесникова О.П., Сафронова И.В. и др. Th1- и Th2-зависимые варианты хронической реакции трансплантат против хозяина // Иммунология. — 2002. — Т. 23, № 3. — С. 143 — 146.
2. Козлов В.А. Гомеостатическая пролиферация лимфоцитов в аспекте иммунопатогенеза различных заболеваний // Иммунология. — 2006. — Т. 27, № 6. — С. 378 — 382.
3. Кудаева О.Т., Гойман Е.В., Лыков А.П., Колесникова О.П. и др. Влияние препаратов, изменяющих соотношение Th1/Th2, на частоту развития клинических вариантов хронической реакции трансплантат против хозяина // Бюллетень экспериментальной биологии и медицины. — 2005. — Т. 140, № 9. — С. 325 — 327.
4. Ткачев В.О., Гойман Е.В., Лыков А.П., Кудаева О.Т. и др. Показатели гемопоэза в динамике развития хронической реакции трансплантат против хозяина // Иммунология. — 2006. — № 3. — С. 168 — 170.
5. Foster M.H. T cells and B cells in lupus nephritis // Semin. Nephrol. — 2007. — Vol. 27, N 1. — P. 47 — 58.
6. Jang E., Kim H.R., Cho S.H., Paik D.J. et al. Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4 T-cell in the K/BxN model // Arthritis Rheum. — 2006. — Vol. 54. — P. 492 — 498.
7. Khoruts A., Fraser J.M. A causal link between lymphopenia and autoimmunity // Immunol. Lett. — 2005. — Vol. 98. — P. 23 — 31.
8. Kimura K., Ida., Shimada K., Kanai Y. Specificity of anti-nuclear antibodies induced in F1 mice undergoing the graft versus host reaction: isotypes and cross-reactivities // Clin. Exp. Immunol. — 1987. — Vol. 69. — P. 385 — 393.
9. Krupica T. Jr., Fry T.J., Mackall C.L. Autoimmunity during lymphopenia: a two-hit model // Clin. Immunol. — 2006. — Vol. 120. — P. 121 — 128.
10. Min B., Yamane H., Hu-Li J., Paul W.E. Spontaneous and homeostatic proliferation of CD4 T-cell are regulated by different mechanisms // J. Immunol. — 2005. — Vol. 174. — P. 6039 — 6044.
11. Shlomchik M.J., Madaio M.P. The role of antibodies and B cells in the pathogenesis of lupus nephritis // Springer Semin. Immunopathol. — 2003. — Vol. 24. — P. 363 — 375.
12. Woodland R.T., Schmidt M.R. Homeostatic proliferation of B-cell // Semin. Immunol. — 2005. — Vol. 17. — P. 209 — 217.
Review
For citations:
Goiman E.V., Tkachev V.O., Kudayeva O.T., Kolesnikova O.P., Kozlov V.A. LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE. Acta Biomedica Scientifica. 2012;(3(2)):267-270. (In Russ.)
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