FEATURES OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH EXTENSIVE PURULENT PERITONITIS
Abstract
We investigated immunological parameters in patients with extensive purulent peritonitis (EPP). It is established that the EPP revealed an imbalance in the immune system which is characterized by a deficiency of cellular part and increased activity of the humoral. Status of cellular immunity is determined by the decrease in the EPP number of T- (primarily through fractions of cytotoxic T-lymphocytes and expressing of late activation. marker), NK- and NKT-cells. In the peripheral blood of patients with EPP increases the content of Th-cells and B1-lymphocytes. Status humoral immunity in the EPP is characterized by increased Ig A and Ig G levels. With the help of correlation analysis and the separate definition of the entropy of the lymphocytes phenotypic composition and immunoglobulins found an increase in regulatory effect on the humoral immunity.
About the Authors
A. A. Savchenko
Research Institute of Medical Problems of the North SB RAMS; Krasnoyarsk State Medical University named after V.F. Voyno-Yasenetskiy
Russian Federation
Russian Federation
D. E. Zditovetskiy
Krasnoyarsk State Medical University named after V.F. Voyno-Yasenetskiy
Russian Federation
Russian Federation
A. G. Borisov
Research Institute of Medical Problems of the North SB RAMS
Russian Federation
Russian Federation
N. A. Luzan
Research Institute of Medical Problems of the North SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
Savchenko A.A., Zditovetskiy D.E., Borisov A.G., Luzan N.A. FEATURES OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH EXTENSIVE PURULENT PERITONITIS. Acta Biomedica Scientifica. 2012;(3(2)):159-163. (In Russ.)
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