DYNAMICS OF SERUM IMMUNOGLOBULINS IN ONCOLOGICAL PATIENTS DURING PERIOPERATIVE PERIOD
Abstract
The aim of the study was to investigate the dynamics of serum immunoglobulins from oncological patients in the perioperative period. As a result of investigations, it was established that already at the initial stage of the intraoperative period the IgM concentration was elevated in patients' sera, and persisted up to 3 days after surgical intervention, while exceeding the values of the control group by 30—80 %. At the same time, no significant changes were detected in IgA and IgG levels of examined patients in the perioperative period. The obtained data confirm the expediency of carrying out the monitoring of immunoglobulin levels in oncological patients both in intra-, and postoperative periods and can be used for the assessment of patient's immune status and in the choice of immunocorrecting therapy strategy.
About the Authors
N. A. Pluzhnikova
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation
Russian Federation
N. Yu. Anisimova
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation
Russian Federation
O. V. Lebedinskaya
E.A. Wagner Perm State Medical Academy
Russian Federation
Russian Federation
D. S. Tsvetkov
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation
Russian Federation
A. P. Godovalov
E.A. Wagner Perm State Medical Academy
Russian Federation
Russian Federation
M. V. Kiselevsky
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation
Russian Federation
References
1. Вышковский Г.Л. Регистр Лекарственных средств России. - М.: РЛС-2009, 2008. - 672 с.
2. Гельфанд Б.Р. Антибиотики при абдоминальной хирургической инфекции // Антибиотики и химиотерапия. - 2001. - № 11. - С. 11-15.
3. Климович В.Б. Регуляторные эффекты иммуноглобулинов // Иммунология. - 1998. -№ 6. - С. 16-17.
4. Berlot G., Viviani M. Immunoglobulins in sepsis // Adv. In. Sepsis. - 2007. - Vol. 6, N 2. -P. 41-46.
5. Dietz S. Low levels of immunoglobulin G in patients with sepsis or septic shock: a signum mali ominis? // Crit. Care. - 2010. - Vol. 14. - P. 26.
6. Jenson H.B., Pollock B.H. The role of intravenous immunoglobulin for the prevention and treatment of neonatal sepsis // Semin. Perinatol. - 1998. -Vol. 22. - P. 50-63.
7. Kyles B.D.M., Baltimore J. Adjunctive use of plasmapheresis and intravenous immunoglobulin therapy in sepsis: a case report // Am. J. Crit. Care. -2005. - Vol. 14, N 2. - P. 109-112.
8. Maier R.V. Pathogenesis of Multiple Organ Dysfunction Syndrome - Endotoxin, Inflammatory Cells, and Their Mediators: Cytokines and Reactive Oxygen Species // Surgical Infections. - 2000. -Vol. 1, N 3. - P. 197-205.
9. Pildal J., Gotzsche P.C. Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review // Clin. Infect. Dis. - 2004. - Vol. 39. -P. 38-46.
10. Tabata N., Azuma E., Masuda S.-I., Ido M. et al. Transient low level of IgG3 induced by sepsis // Pediatrics International. - 1995. - Vol. 37, N 2. -P. 201 -202.
11. Talmor M. Relationship of systemic inflammatory response syndrome to organ dysfunction, length of stay, and mortality in critical surgical illness: effect of intensive care unit resuscitation // Arch. Surg. -1999. - Vol. 134. - P. 81-87.
Review
For citations:
Pluzhnikova N.A., Anisimova N.Yu., Lebedinskaya O.V., Tsvetkov D.S., Godovalov A.P., Kiselevsky M.V. DYNAMICS OF SERUM IMMUNOGLOBULINS IN ONCOLOGICAL PATIENTS DURING PERIOPERATIVE PERIOD. Acta Biomedica Scientifica. 2012;(3(2)):148-150. (In Russ.)
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