M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
Abstract
The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells was conducted in 13 patients with ischemic (n = 10) and hemorrhagic (n = 3) brain stroke. At 6 months after cells administration all the patients had clinical Improvement. NIHS score decreased from 8,6 ± 1,06 to 4,4 ± 0.55 (p = 0,0008), several patients showed the decrease of sensitiveness impairments, improvement of cognitive functions and enhanced quality of life. Thus, we demonstrated an ability of generation M2-like macrophages from patients with brain stroke. Endolumbar administration of these cells was safe andi didn't cause severe adverse effects and complications andi — in preliminary data — improvedi motional and cognitive functions.
About the Authors
S. A. Morozov
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
G. V. Tomash
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
E. Ya. Shevela
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
L. V. Sakhno
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
A. V. Smyk
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
N. M. Starostina
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
A. A. Ostanin
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
E. R. Chernykh
Research Institute of Clinical Immunology SD RAMS
Russian Federation
Russian Federation
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Review
For citations:
Morozov S.A., Tomash G.V., Shevela E.Ya., Sakhno L.V., Smyk A.V., Starostina N.M., Ostanin A.A., Chernykh E.R. M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT. Acta Biomedica Scientifica. 2012;(3(2)):125-128. (In Russ.)
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