THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
Abstract
Cell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lower counts of granulocytes. Significant increase of relative numbers of dividing CD34+ cells (in S, G2/M phases of the cell cycle) was demonstrated, in acute leucosis patients' grafts. In lymphoma grafts the levels of CD34+ cells in G0/G1 phases were found, to be increased. Cells isolated from grafts of acute leucosis patients characterized by higher levels of proinflammatory cytokines production, such as IL-1, IL-6, MIP-1β, TNF-α, IL-8, IFN-γ (the last two ones— non-significant trend) and cytokines, essential for humoral immune response (IL-4 and — in trend — IL-10). The existing differences didn't influence on effectiveness of early lymphocyte recovery.
About the Authors
D. S. Baranova
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
L. V. Sakhno
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
I. V. Kruchkova
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
N. V. Pronkina
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
M. A. Tikhonova
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
E. V. Batorov
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
A. V. Gilevich
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
V. V. Sergeyevicheva
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
S. A. Sizikova
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
G. Yu. Ushakova
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
A. A. Ostanin
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
T. I. Pospelova
Novosibirsk State Medical University
Russian Federation
Russian Federation
E. R. Chernykh
Federal State Research Institute of Clinical Immunology SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
Baranova D.S., Sakhno L.V., Kruchkova I.V., Pronkina N.V., Tikhonova M.A., Batorov E.V., Gilevich A.V., Sergeyevicheva V.V., Sizikova S.A., Ushakova G.Yu., Ostanin A.A., Pospelova T.I., Chernykh E.R. THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS. Acta Biomedica Scientifica. 2012;(3(2)):29-32. (In Russ.)
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