ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
https://doi.org/10.29413/ABS.2018-3.4.17
Abstract
Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body, significant increase in oxygen consumption followed by activation of the lipid peroxidation and decrease of endogenic antioxidant system efficacy.
The aim of the present study was to evaluate the influence of the complex plant remedy on exercise tolerance of laboratory animals and to reveal mechanisms increasing physical endurance.
Materials and methods. The experiments were carried out on white Wistar rats weighing 190-220 g. The physical endurance of the animals was estimated by recording time of weighted swimming to complete exhaustion in the pool. The weighting was 7 % of the body mass. The water solution of the dry extract derived from five medicinal plants was introduced intragastrically to the animals of the experimental group at the dose of 100 mg/kg in the volume of 10 ml/kg for 7 days (once a day), an hour before testing. The content of ATP, lactic acid and pyruvic acid were determined in the skeletal muscle homogenate; glycogen was determined in the liver homogenate; in the blood serum there was estimated concentration of malonic dialdehyde, the activity of catalase; the concentration of reduced glutathione was determined in the whole blood and the activity of superoxide dismutase was estimated in erythrocytes.
Conclusion. The course introduction of the complex plant remedy to rats results in resilience to intensive physical exertion due to optimization of energy metabolism, inhibition of free-radical biomacromolecule oxidation processes and increase in endogenic antioxidant system activity.
About the Authors
B. A. MuruevRussian Federation
ul. Sakhyanova 6, Ulan-Ude 670047, Russian Federation
Postgraduate at the Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology SB RAS
tel. (3012) 43-37-13
A. G. Mondodoev
Russian Federation
ul. Sakhyanova 6, Ulan-Ude 670047, Russian Federation
ul. Oktyabrskaya 36a, Ulan-Ude 670002, Russian Federation
Doctor of Medical Sciences, Head of the Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology SB RAS; Acting Professor at the Department of General Medicine, Medical Institute, Buryat State University
I. E. Matkhanov
Russian Federation
ul. Oktyabrskaya 36a, Ulan-Ude 670002, Russian Federation
Candidate of Biological Sciences, Senior Research Officer at the Department of Pharmacology and Traditional Medicine, Medical Institute, Buryat State University
tel. (3012) 42-82-55
A. A. Toropova
Russian Federation
ul. Sakhyanova 6, Ulan-Ude 670047, Russian Federation
ul. Oktyabrskaya 36a, Ulan-Ude 670002, Russian Federation
Candidate of Biological Sciences, Research Officer at the Laboratory of Biologically Active Substances Safety, Institute of General and Experimental Biology SB RAS
tel. (3012) 43-37-13, fax (3012) 43-30-34
L. N. Shantanova
Russian Federation
ul. Sakhyanova 6, Ulan-Ude 670047, Russian Federation
ul. Oktyabrskaya 36a, Ulan-Ude 670002, Russian Federation
Doctor of Biological Sciences, Professor, Head of the Laboratory of Biologically Active Substances Safety, Institute of General and Experimental Biology SB RAS
tel. +7 (3012) 43-37-13
O. G. Dimitrov
Russian Federation
ul. Sakhyanova 6, Ulan-Ude 670047, Russian Federation
Postgraduate at the Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology SB RAS
O. V. Yundunova
Russian Federation
ul. Oktyabrskaya 36a, Ulan-Ude 670002, Russian Federation
Candidate of Medical Sciences, Senior Lecturer at the Department of General Medicine, Medical Institute, Buryat State University
tel. +7 (3012) 42-82-55
I. S. Butukhanova
Russian Federation
ul. Oktyabrskaya 36a, Ulan-Ude 670002, Russian Federation
Candidate of Medical Sciences, Senior Lecturer at the Department of General Medicine, Medical Institute, Buryat State University
tel. (3012) 42-82-55
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Review
For citations:
Muruev B.A., Mondodoev A.G., Matkhanov I.E., Toropova A.A., Shantanova L.N., Dimitrov O.G., Yundunova O.V., Butukhanova I.S. ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY. Acta Biomedica Scientifica. 2018;3(4):120-124. (In Russ.) https://doi.org/10.29413/ABS.2018-3.4.17