CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
https://doi.org/10.29413/ABS.2018-3.4.7
Abstract
The subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific antibodies in persons vaccinated against TBE.
The aim of the present study is to show the differences in biological properties on the model of two strains of Far Eastern TBEV subtype belonging to different clusters and to substantiate the need for a personalized approach to the vaccine prophylaxis of tick-borne encephalitis.
Results. Two strains of TBEV were used in the studies. On the basis of full genome sequencing the Dal’negorsk strain (FJ402886, GenBank) is referred to the typical representative of Sofjin-like, and Primorye-437 (JQ825162, GenBank) – to Oshima-like TBEV strains of the Far Eastern subtype.The experiment shows the levels of specific antibodies capable of neutralizing virulence strains of tick- borne encephalitis virus. Low antibody titers (1:100 and 1:400) can neutralize only a low dose of a non-virulent strain of tick-borne encephalitis virus. Reliable protection against the disease of people infected with virulent strains of the TBEV can provide only a high level of specific antibodies.
Conclusion. If the level of specific antibodies of IgG is 1:400 or lower, the vaccination course should be continued, at a titer of antibodies above 1:400, revaccination can be postponed subject to annual monitoring of specific immunity parameters in the pre-epidemic TBE season.
About the Author
G. N. Leonova
Somov Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
ul. Selskaya 1, Vladivostok 690087, Russian Federation
Doctor of Medical Sciences, Professor, Chief Research Officer at the Laboratory of Natural-Focal Transmissible Infections, Somov Research Institute of Epidemiology and Microbiology
tel. (4232) 44-07-12
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For citations:
Leonova G.N. CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION. Acta Biomedica Scientifica. 2018;3(4):42-46. (In Russ.) https://doi.org/10.29413/ABS.2018-3.4.7
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