Preview

Acta Biomedica Scientifica

Advanced search

PHARMACOECONOMICS OF APPLICATION OF HEPATOPROTECTORS IN THERAPY OF DRUG-INDUCED LIVER INJURY AFTER CHEMOTHERAPY

https://doi.org/10.12737/article_59a614fb8002d5.90108157

Abstract

One of the major problems of modern oncology drug is liver damage, requiring additional costs for its treatment. The aim of our work was to study medical and economic efficiency of various schemes of hepatoprotective treatment of toxic liver damage. The paper presents the use of pharmacoeconomic studies in the treatment of hepatic drug-induced hepatitis, which occurs after chemotherapy in patients with Hodgkin's lymphoma. The study was conducted in the two comparison groups on a "cost - effectiveness". This method was chosen because it is in effect depending on the process (method), treatment was varied, as well as costs incurred. The unit of the effect of the number of days required for the relief of hepatic failure has been selected. Economic analysis of the work includes not only toxic hepatitis therapy, and treatment of any disease complications such as hepatic encephalopathy. The study revealed that the effectiveness of therapy increased 1.4 times and the economic costs were 51.8 % reduced with hepatoprotective drug "remaxol".

About the Authors

D. D. Morikov
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education
Russian Federation


E. G. Morikova
Irkutsk Aviation Plant - Branch of the Irkut Corporation
Russian Federation


D. M. Ponomarenko
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education
Russian Federation


References

1. Демина Е.А. Дискуссионные вопросы лечения распространённых стадий лимфомы Ходжкина // Злокачественные опухоли. - 2013. - № 2. - С. 18-22

2. Мориков Д.Д., Тетерина Т.П. Первый опыт применения гепатопротектора «Ремаксол» при лечении печёночной недостаточности в онкологии // Актуальные проблемы анестезиологии и реаниматологии: Матер. VIII Байкальского конгресса. - Иркутск, 2011. - С. 46-47

3. Мориков Д.Д., Тетерина T.P. Применение гепатопротектора ремаксол при лечении печеночной недостаточности в онкологии // Современные аспекты анестезиологии и интенсивной терапии. Пусковые факторы критических состояний: Матер. IX межрегион. науч.-практ. конф. (24-25 февраля 2012). - Новосибирск, 2012. - С. 269-270

4. Применение клинико-экономического анализа в медицине / Под ред. А.В. Решетникова. - М.: ГЭОТАР-Медиа, 2009. - 179 c

5. Руководство по химиотерапии опухолевых заболеваний / Под ред. Н.И. Переводчикова. - М.: Практическая медицина, 2011. - 518 с

6. Шкляев С.С., Павлов В.В. Лимфома Ходжкина и «новый старый» Бендамустин // Клиническая онкогематология. - 2013. - № 2. - С. 139-147


Review

For citations:


Morikov D.D., Morikova E.G., Ponomarenko D.M. PHARMACOECONOMICS OF APPLICATION OF HEPATOPROTECTORS IN THERAPY OF DRUG-INDUCED LIVER INJURY AFTER CHEMOTHERAPY. Acta Biomedica Scientifica. 2017;2(2):54-58. (In Russ.) https://doi.org/10.12737/article_59a614fb8002d5.90108157

Views: 638


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2541-9420 (Print)
ISSN 2587-9596 (Online)