Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
https://doi.org/10.29413/ABS.2018-3.3.18
Abstract
Background: Among the subjects of the Russian Federation, Irkutsk region is an area with an unfavorable epidemiological situation for HIV-infection. Women living with HIV in Russia and visiting AIDS-centers represent a socially and economically active part of the population are at a young reproductive age and plan to have children. Aims: to study the state of the neuroendocrine system and the ovarian reserve in HIV-infected women with reproductive disorders. Materials and methods. We examined in 17 HIV-infected women with reproductive disorders and 33 women with HIV-infection and reproductive health at the age of 18-45 years (mean age 31,1 ± 4,4 years). The determination of hormone levels was carried out by a competitive solid-phase enzyme-linked immunosorbent assay. Results. The obtained results testify to neuroendocrine disorders in the form of a decrease in the level of total testosterone, 17-OH progesterone, dehydroepiandrosterone sulfate, as a manifestation of androgen deficiency of the body, as a result of ovarian dysfunction. Decrease in the level of Anti-Mullerian Hormone and increase the content of follicle-stimulating hormone, as a manifestation of the beginning of early menopause or a factor leading to infertility. Conclusions. The results of this study show that a woman's body on the background of HIV-infection reveals disorders of the neuroendocrine system dysfunction and decreased ovarian ovarian reserve, and as a result, reproductive disorders.
About the Authors
E. V. Genich
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
O. Y. Leshenko
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
M. A. Darenskaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
L. F. Sholokhov
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Колесникова Л.И., Колесников С.И., Даренская М.А., Гребенкина Л.А., Тимофеева Е.В., Лещенко О.Я., Вантеева О.А., Рашидова М.А. Оценка про- и антиоксидантного статуса у женщин с ВИЧикоинфекцией І/ Терапевтический архив. - 2016. - Т. 88, № 11. - С. 17-21
2. Латышева И.Б., Додонов К.Н., Воронин Е.Е. Перинатальная профилактика ВИЧ-инфекции в регионах РФ || ВИЧ-инфекция и иммуносупрессия. -2012. - № 4 (3). - С. 71-77
3. Садовникова В.Н. Эпидемиологические особенности ВИЧ-инфекции у беременных женщин и рождённых ими детей || Эпидемиология и инфекционные болезни. - 2010. - № 1. - С. 8-13
4. Тимофеева Е.В., Лещенко О.Я. Современные представления о репродуктивном здоровье и потенциале у женщин с ВИЧ-инфекцией и вирусными гемоконтактными гепатитами || Бюл. ВСНЦ СО РАМН. - 2014. - № 3 (97). - С. 128-132
5. Brown T.T. (2011). The effects of HIV-1 infection on endocrine organs. Best Pract Res Clin Endocrinol Metab, 25 (3), 403-413.
6. Cejtin H., Kalinowski A., Bacchetti P., Taylor R.N., Watts D.H., Kim S., Massad L.S., Preston-Martin S., Anastos K., Moxley M., Minkoff H.L. (2006). Effects of human immunodeficiency virus on protracted amenorrhea and ovarian dysfunction. Obstet Gynecol, 108 (6), 1423-1431.
7. Choi H.H., Gray P.B., Storer T.W., Calof O.M., Woodhouse L., Singh A.B., Padero C., Mac R.P., Sinha-Hikim I., Shen R., Dzekov J., Dzekov C., Kushnir M.M., Rockwood A.L., Meikle A.W., Lee M.L., Hays R.D., Bhasin S. (2005). Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss. J Clin Endocrinol Metab, 90 (3), 1531-1541.
8. Clark R., Mulligan K., Stamenovic E., Chang B., Watts H., Andersen J., Squires K., Benson C. (2001). Frequency of anovulation and early menopause among women enrolled in selected adult AIDS clinical trials group studies. J Infect Dis, 184 (10), 1325-1327.
9. Dolan S., Collins M., Lee H., Grinspoon S. (2009). Effects of long-term testosterone administration in HIV-infected women: a randomized, placebo-controlled trial. AIDS, 23 (8), 951-959.
10. Dolan S., Grinspoon S. (2005). Androgen deficiency and the role of testosterone administration in HIV-infected women. J Acquir Immune Defic Syndr, 38, 48-49.
11. Dolan S., Wilkie S., Aliabadi N., Sullivan M.P., Basgoz N., Davis B., Grinspoon S. (2004). Effects of testosterone administration in human immunodeficiency virus-infected women with low weight: a randomized placebo-controlled study. Arch Intern Med., 164 (8), 897-904.
12. Highleyman L. (2004). HIV and hormones. San Francisco AIDS Foundation, 16 (4), 67-79.
13. Hoffmann C., Brown TT. (2007). Thyroid function abnormalities in HIV-infected patients. Clin Infect Dis, 45 (4), 488-494.
14. Kalra S., Sleim H., Kotwal N. (2011). Human immunodeficiency virus and the endocrine system. Indian J Endocrinol Metab, 15 (4), 231-233.
15. Kibiriqe D., Ssekitoleko R. (2013). Endocrine and metabolic abnormalities among HIV-infected patients: a current review. Int J STD AIDS, 24 (8), 603-611.
16. Kushnir V., Lewis W. (2011). HIV|AIDS and infertility: emerging problems in the era of highly active antiretrovirals. Fertil Steril, 96 (3), 546-553.
17. Ohl J., Partisani M., Demangeat C., Binder-Foucard F., Nisand I., Lang J.M. (2010). Alterations of ovarian reserve tests in Human Immunodeficiency Virus (HIV)-infected women. Gynecol Obstet Fertil, 38 (5), 313-317.
18. Scherzer R., Bacchetti P., Messerlian G., Goderre J., Maki P.M., Seifer D.B., Anastos K., Karim R., Greenblatt R.M. (2015). Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian hormone levels in a large cohort of HIV-infected and HIV-uninfected women. Am J Reprod Immunol, 73 (3), 273-284.
19. Seifer D., Golub E., Lambert-Messerlian G., Springer G., Holman S., Moxley M., Cejtin H., Nathwani N., Anastos K., Minkoff H., Greenblatt R. (2007). Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women. Fertil Steril, 88 (6), 1645-1652.
20. Sherr L., Nagra N., Kulubya G., Catalan J., Clucas C., Harding R. (2011). HIV infection associated post-traumatic stress disorder and post-traumatic growth - a systematic review. Psychol Health Med, 16 (5), 612-629.
21. Varthakavi P.K. (2009). Thyroid dysfunction in HIV-AIDS. JAPI, 57 (7), 503-504.
22. Willems N., Lemoine C., Liesnard C., Gervy C., Hien A.D., Karama R., Somda I., Englert Y. (2013). Is ovarian function impaired in HIV patients? A clinical pilot study in Burkina Faso. Rev Med Brux, 34 (5), 397-404.
23. Zapanti E., Terzidis K., Chrousos G. (2008). Dysfunction of the hypothalamic-pituitary-adrenal axis in HIV infection and disease. Hormones, 7 (3), 205-216.
Review
For citations:
Genich E.V., Leshenko O.Y., Darenskaya M.A., Sholokhov L.F. Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders. Acta Biomedica Scientifica. 2018;3(3):116-120. (In Russ.) https://doi.org/10.29413/ABS.2018-3.3.18
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