Experimental study of the effectiveness of a nafion-coated polypropylene endoprosthesis in plastic surgery of the anterior abdominal wall

Justification. The search for various materials in hernia repair is an urgent task of herniology.

The aim of the study was to study the effectiveness of using polypropylene endoprostheses with a nafion coating in the plastic of the anterior abdominal wall in experimental animals.

Materials and methods. A prospective non-randomized study in the vivarium of Kabardino-Balkarian University was used 16 mongrel rabbits divided into 2 equal groups. The first group underwent implantation of a polypropylene mesh using the “on-lay” technique; the second group underwent a similar operation; but using a nafion-coated endoprosthesis. On the 7th; 14th; 21st; and 30th days; 4 individuals were removed from the experiment; followed by tissue sampling from the anterior abdominal wall using an endoprosthesis and the production of paraffin blocks and slides for histological examination and morphometry. The clinical and laboratory dynamics were evaluated. The tissues in the endoprosthetics area were subjected to a tear strength test. The SPSS 17.0 program was used for statistical processing.

Results. In the control group; the fibers of the newly formed connective tissue were chaotic with a large number of cellular infiltrates. In the experimental group; the fiber flow was orderly and corrugated. Morphometric parameters of fibrillogenesis were statistically significantly higher in the experimental group. According to the results of a clinical blood test in the control group; there was a statistically significant increase in leukocytes and C-reactive protein. In individuals of this group; an increase in blood creatinine was noted against the background of a systemic inflammatory reaction. Suppuration in the control group was 50 % more than in the experimental group. The force required to rupture the anterior abdominal wall tissue with an endoprosthesis was statistically significantly greater in the experimental group than in the experimental group.

Conclusion. The use of a polypropylene endoprosthesis with a nafion coating leads to an improvement in regeneration processes in the area of its implantation on the anterior abdominal wall in rabbits.

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