Bone remodeling in women with diabetes mellitus
https://doi.org/10.12737/article_5a3a0d8f913509.24544012
Abstract
Background. 1t is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent researches established the multidirectional changes of bone remodeling markers in women with type 2 DM at different age periods. Aims: to study the condition of bone remodeling in women with type 2 DM at different age periods. Materials and methods. We examined 27 women with type 2 DM, among them 15 were in the post-menopausal period and 12 with preserved menstrual function. Levels of osteocalcin, N-terminal propeptide of type 1 collagen (P1NP), C-terminal telopeptide of type 1 collagen (β-Crosslaps), 25-OH vitamin D, the ionized calcium were researched. Results. The analysis showed that increase in β-Crosslaps levels, P1NP, levels of osteocaltcin were observed in women with type 2 DM in the post-menopausal period, compared to parameters of women with type 2 DM with preserved menstrual function. Inverse correlation relation of osteocaltcin and 25-OH vitamin D was revealed in women with type 2 DM. Conclusion. Significant increase in markers of osteosynthesis and osteoresorption in women with type 2 DM was shown in the post-menopausal period compared with indicators of women with type 2 DM with preserved menstrual function.
About the Authors
T. P. Bardymova
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
M. V. Mistyakov
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Y. A. Basharina
Irkutsk City Hospital N 1
Russian Federation
Russian Federation
E. B. Minaeva
Irkutsk Diagnostic Center
Russian Federation
Russian Federation
A. S. Abzaeva
Regional Hospital N 2
Russian Federation
Russian Federation
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Review
For citations:
Bardymova T.P., Mistyakov M.V., Basharina Y.A., Minaeva E.B., Abzaeva A.S. Bone remodeling in women with diabetes mellitus. Acta Biomedica Scientifica. 2017;2(5(2)):33-36. (In Russ.) https://doi.org/10.12737/article_5a3a0d8f913509.24544012
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