DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
https://doi.org/10.12737/article_59fad5149bcb24.36563455
Abstract
Background. It is known that obstructive sleep apnea (OSA) has been closely linked to essential hypertension (EH) and is considered as an important stressor. The hypothalamic-pituitary-adrenal axis (HPA) is a major component involved in stress response. However, the response of HPA axis to OSA effects may be variable. Aim: to estimate hormonal status in OSA and non-OSA adolescents with EH. Methods. We examined 38 male adolescents with EH (18 OSA patients - group A, 20 non-OSA patients - group B) aged 14-17 years. OSA was verified by polysomnography applying system GRASS-TeLeFACTOR Twin PSG (Comet, USA). EH was diagnosed with 24-h ambulatory blood pressure monitoring using monitor Oscar 2 for OXFORD Medilog Prima. Hormonal status, including thyroid-stimulating hormone (TSH), prolactin (PRL) and cortisol, were routinely collected using an automatic analyzer «Cobos ELL» (USA) and test-system «Alcor-bio» (Russia). All differences were considered significant at p < 0.05. Results. There were statistically significant differences in morning serum cortisol level of OSA adolescents (745.8 ± 6.4 nmol/L versus 493.2 ± 3.2 nmol/L in non-OSA participants; р < 0.05). Morning serum PRL and TSH levels in the both groups no statistically significant differences, but there is a trend towards its increasing in OSA adolescents with EH (482.8 ± 4.2 mME/L in the group A and 442.2 ± 4.1 mME/L in the group B, and 1.95 ± 0.9 mkME/ml versus 1.5 ± 0.2 mkME/ml, respectively, р < 0.05). Conclusion. The results of this study indicate for chronic stress if OSA in adolescents with EH is present. This is due to the influence of sleep fragmentation and intermittent hypoxia on HPA axis with compensatory stress-related hormones release.
About the Authors
O. N. Berdina
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
L. F. Sholokhov
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
L. V. Rychkova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
I. M. Madaeva
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Долгих В.В., Рычкова Л.В., Погодина A.B., Кулеш Д.В., Бугун О.В., Мандзяк Т.В., Храмова Е.Е., Валявская О.В. Программа дифференцированного наблюдения за детьми и подростками с синдромом артериальной гипертензии // Бюл. ВСНЦ СО РАМН. -2007. - № 2. - С. 19-23
2. Колесникова Л.И., Даренская М.А., Долгих В.В., Шолохов Л.Ф., Шенин В.А., Гребенкина Л.А., Долгих М.И. Особенности изменений показателей гипофизарно-тиреоидной системы и липидного обмена у подростков разных этнисеских групп // Клиническая лабораторная диагностика. - 2012. - № 2. - С. 19-22
3. Люсов В.А., Евсиков Е.М., Машукова Ю.М., Шарипов Р.А. Частота эндокринных нарушений и характер гормонального дисбаланса при кризовом течении первичной артериальной гипертензии // Российский кардиологический журнал. - 2008. - № 1 (69). - С. 4-16
4. Мадаева И.М., Петрова В.А., Колесникова Л.И., Шевырталова О.Н. Синдром обструктивного апноэ/ гипопоэ сна и перекисное окисление липидов // Пульмонология. - 2009. - № 2. - C. 65-69
5. Пальман А.Д. Синдром обструктивного апноэ во сне в терапевтической практике / Под ред. А.И. Синопальникова. - М.: Медицина, 2007. - 77 с
6. Петров В.И., Ледяев М.Я. Оценка суточного ритма артериального давления у детей. - Волгоград, Н. Новгород, 2006. - 78 с
7. Шевырталова О.Н., Протопопова О.Н., Мадаева И.М., Долгих В.В., Колесникова Л.И., Поляков В.М., Прохорова Ж.В. Нарушения сна в генезе эмоционально-личностных и когнитивных расстройств у подростков с эссенциальной гипертензией // Российский педиатрический журнал.- 2011. - № 2.-С. 12-16
8. Шустов С.Б., Яковлев В.А., Баранов В.Л. Артериальные гипертензии. - СПб.: Спец. лит., 2003 - 320 с
9. Blechner M, Williamson A.A. (2016). Consequences of obstructive sleep apnea in children. Curr. Probl. Pediatr. Adolesc. Health Care., 46 (1), 19-26.
10. Dempsey J.A, Veasey S.C, Morgan B.J. (2010). Pathophysiology of sleep apnea. Physiol. Rev., 90, 47-112.
11. Goncharova N.D, Chigarova O.A, Oganyan T.E. (2017). Response of the hypothalamic-pituitary-adrenal system to repeated moderate psychoemotional stress exposure is associated with behavioral parameters. Bull. Exp. Biol. Med., 163 (1), 95-98.
12. Iber C, Ancoli-Israel S, Chesson A.L. (2007). AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specifications. Westchester, 51 p.
13. Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey J.A, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia M.A, Mehra R, Pack A.I, Polotsky V.Y, Redline S, Somers V.K. (2017). Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. J. Am. Coll. Cardiol., 69 (7), 841-858.
14. Javaheri S, Drager L.F, Lorenzi-Filho G. (2017). Sleep and cardiovascular disease: present and future. In: Kryger M.H, Roth T, Dement W.C. (eds.). Principles and practices of sleep medicine. Philadelphia, PA, 1222-1228.
15. Kalliolia E, Silajdzic E, Nambron R, Costelloe S.J, Martin N.G, Hill N.R, Frost C, Watt H.C, Hindmarsh P, Björkqvist M, Warner T.T. (2015). A 24-hour study of the hypothalamo-pituitary axes in Huntington’s disease. PLoS One, 10 (10), e0138848.
16. Lee-Chiong T.L, Sateia M.J, Carskadon M.A. (2002). Sleep Medicine. 737 p.
17. Lyons O.D, Bradley T.D. (2015). Heart failure and sleep apnea. Can. J. Cardiol., 31, 898-908.
18. Mozaffarian D, Benjamin E.J, Go A.S. (2016). Heart disease and stroke statistics - 2016 update: a report from the American Heart Association. Circulation, 133, e38-e360.
19. Peppard P.E, Young T, Barnet J.H. (2013). Increased prevalence of sleep-disordered breathing in adults. Am. J. Epidemiol., 177, 1006-1014;
20. Schmid S.M, Hallschmid M, Jauch-Chara K, Kück M.C, Lehnert H, Schultes B. (2003). Partial sleep restriction modulates secretory activity of thyrotropic axis in healthy men. J. Sleep Res., 22 (2), 166-169.
Review
For citations:
Berdina O.N., Sholokhov L.F., Rychkova L.V., Madaeva I.M. DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA. Acta Biomedica Scientifica. 2017;2(4):53-57. (In Russ.) https://doi.org/10.12737/article_59fad5149bcb24.36563455
Views:
674
Email this article 
