Preview

Acta Biomedica Scientifica

Advanced search

ASSESSMENT OF THE STEROID THERAPY EFFECTIVENESS IN COMPLEX TREATMENT OF ACUTE PURULENT RHINOSINUSITIS IN CHILDREN

https://doi.org/10.12737/article_5955e6b458cc60.57462709

Abstract

Material and methods. The control group consisted of 166 children with acute purulent rhinosinusitis who underwent standard treatment: antibiotic therapy, on the strict condition - endonasal drainage of the maxillary sinuses, the treatment method around Proets, physiotherapy of the nose, vasoconstrictor nose drops. The main group consisted of 132 children with acute purulent rhinosinusitis, who, in addition to standard treatment, were prescribed topical corticosteroid - mometasone furoate. Results. The concentration of lactoferrin (in the main group) was normalized due to the action of the nasonex spray, which proves a high anti-inflammatory effect of the combined treatment. There was a statistically significant difference in the groups after 7 days and 1 month after treatment (t = 1.96; p = 0.05). Based on the data of Mac-Nimar criterion (X2 = 11.204, with the probability of error p = 0.002) in the control group compared to the primary (x2=9.202, with the probability of error p < 0.0001), treatment was less effective. Conclusion. The use of inhalative topical glucocorticosteroid in treatment of children with acute purulent rhinosinusitis allows to achieve a positive clinical effect and the concentration of lactoferrin can serve as an important criterion of the effectiveness of treatment.

About the Author

O. V. Borovikova
Novokuznetsk State Institute of Postgraduate Medicine
Russian Federation


References

1. Карпищенко С.А., Кучерова Л.Р., Долгов О.И. Опыт использования мометазона фуроата (назонекс) при острых риносинуситах // Российская ринология. - 2011. - № 1. - С. 27.

2. Рациг Е.Ю., Малыгина Л.В. Риносинусит у детей // Педиатрия. - 2013. - № 4. - С. 64-66.

3. Тулупов Д.А., Карпова Е.П. Назальный спрей мометазона фуроата в терапии хронического аде-ноидита у детей // Эффективная фармакотерапия. Педиатрия. - 2013. - № 2. - С. 18-19.

4. Berlucchi M., Salsi D., Valetti L., Parrinello G., Nicolai P. (2007). The role of mometasone furoate aqueous nasal spray in the treatment of adenoidal hypertrophy in the pediatric age group: preliminary results of a prospective, randomized study [Rol’ vodnogo nasal’nogo spreya mometazona furoata v letsenii gipertrofii adenoidov v detskoi vozrastnoi gryppe: predvaritel’nye rezyl’taty prospektivnogo, randomizirovannogo issledovaniya]. Pediatrics, 119 (6), 1392-1397.

5. Brock J.H. (2012). Lactoferrin - 50 years. Biochem. Cell Biol., 90 (3), 245-251.

6. Latorre D., Berlutti F., Valenti P. (2012). LF immunomodulatory strategies: mastering bacterial endotoxin. Biochem. Cell Biol., 90 (3), 269-278.

7. Legrand D., Elass E., Carpenter M., Mazurer J. (2010). Lactoferrin: a modulator of immune and inflammatory responses. Cell Mol. Life Sci., (62), 2549-2559.

8. Psaltis A.J., Bruhn M.A., Ooi E.H., Tan L.W., Wormald P.J. (2011). Nasal mucosa expression of lactoferrin in patients with chronic rhinosinusitis. Laryngoscope, 117 (11), 2030-2035.

9. Zhang L., Mendoza-Sassi R.A., César J.A., Chadha N.K. (2008). Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy. Cochrane Database Syst. Rev., 16 (3), CD006286, pub2.


Review

For citations:


Borovikova O.V. ASSESSMENT OF THE STEROID THERAPY EFFECTIVENESS IN COMPLEX TREATMENT OF ACUTE PURULENT RHINOSINUSITIS IN CHILDREN. Acta Biomedica Scientifica. 2017;2(1):24-27. (In Russ.) https://doi.org/10.12737/article_5955e6b458cc60.57462709

Views: 639


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2541-9420 (Print)
ISSN 2587-9596 (Online)