Regional features of the epidemiology of pterygium in the Republic of Bashkortostan
https://doi.org/10.29413/ABS.2022-7.1.10
Abstract
Background. Pterygium is ubiquitous and multifactorial; today, information on the prevalence of pterygium, risk factors, the relationship of its development with concomitant pathology and the type of life activity of patients in various regions of Russia is limited. All of the above led to the conduct of this epidemiological study in the Republic of Bashkortostan.
The aim of the study: to study the prevalence of pterygium, as well as to identify the relationship of risk factors for its development with the type of life activity and concomitant diseases in the urban and rural population of the Republic of Bashkortostan.
Methods. On the basis of the Ufa Research Institute of Eye Diseases, within the framework of the Ural Eye and Medical Study (UEMS) research project, a population study of people living in urban and rural regions of the Republic of Bashkortostan was carried out. The study involved 5899 people, including men – 43.7 % (2585 people), women – 56.3 % (3314 people), urban residents made 42.3 % (2491 people), rural – 57.7 % (3408 people).
Results. As a result of our study, pterygium was diagnosed in 138 people (204 eyes – 2.3 %) (95% CI: 2.0–2.7 %). One-way analysis showed a higher prevalence of pterygium associated (p˂0.10) with a number of systemic and ophthalmic parameters. However, according to the results of multivariate analysis, it was revealed that the prevalence of pterygium was significantly associated with older age (p = 0.006), rural area of residence (p = 0.001) and low educational level (p = 0.03).
Conclusion. The prevalence of pterygium in Republic of Bashkortostan according to the UEMS study was 2.3 %, or 23 people per 1000 population among people over 40 years old. The nature of the settlement influences the prevalence of pterygium in the Republic of Bashkortostan. Pterygium was more common among older people among all respondents who took part in the study. In the study, pterygium was not a biomarker of general somatic diseases.
About the Authors
M. M. BikbovRussian Federation
Dr. Sc. (Med.), Professor, Corresponding Member of the Academy of Sciences of the Republic of Bashkortostan, Director,
Pushkina str. 90, Ufa 450008
V. K. Surkova
Russian Federation
Dr. Sc. (Med.), Professor, Senior Research Officer at the Department of Cornea,
Pushkina str. 90, Ufa 450008
R. A. Kazakbaev
Russian Federation
Head of the Second Microsurgical Department,
Pushkina str. 90, Ufa 450008
References
1. Iureva TN, Shchuko AG, Poryadin VR, Batoroev YK, Kuzmin SV. The role of growth factors in the formation and progression of pterygium. Fyodorov Journal of Ophthalmic Surgery. 2013; (4): 60-64. (In Russ.).
2. Petraevsky AV, Trishkin KS. Pterygium. Etiopathogenesis, clinic, treatment. Volgograd: Panorama; 2018. (In Russ.).
3. Fotouhi A, Hashemi H, Khabazkhoob M, Mohammad K. Prevalence and risk factors of pterygium and pinguecula: the Tehran Eye Study. Eye (Lond). 2009; 23(5): 1125-1129. doi: 10.1038/eye.2008.200
4. Lin YH, Sun Ch-Ch, Yeung L, Yu-Wei Yi, Ming-Hui S, KuanJen Ch. Epidemiologic study of pterygium in Taiwan. Jpn J Ophthalmol. 2019; 63(4): 297-303. doi: 10.1007/s10384-019-00670-x
5. Liu L, Wu J, Geng J, Yuan Z, Huang D. Geographical prevalence and risk factors for pterygium: A systematic review and meta-analysis. BMJ Open. 2013; 3(11): e003787. doi: 10.1136/bmjopen-2013-003787
6. Bikbov M, Fayzrakhmanov R, Kazakbaeva G, Jonas JB. Ural Eye and Medical Study: Description of study design and methodology. Ophthalmic Epidemiol. 2018; 25(3): 187-198. doi: 10.1080/09286586.2017.1384504
7. World Medical Association. Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA. 2013; 310(20): 2191-2194. doi: 10.1001/jama.2013.281053
8. Bikbov M, Zainullin R, Kazakbaeva G, Gilmanshin T, Salavatova V, Arslangareeva I, et al. Pterygium prevalence and its associations in a Russian population: The Ural Eye and Medical Study. Am J Ophthalmol. 2019; 205: 27-34. doi: 10.1016/j.ajo.2019.02.031
9. Wanzeler ACV, Barbosa IAF, Duarte B, Borges D, Barbosa EdB, Kamiji D, et al. Mechanisms and biomarker candidates in pterygium development. Arquivos Brasileiros de Oftalmologia. 2019; 82(6): 528-536. doi: 10.5935/0004-2749.20190103
10. Cherednichenko LP, Korenyak GV, Zhitenko NA. Role of ecologogeographical factors in development pterygium. Medical News of the North Caucasus. 2006; 2(2): 56-57. (In Russ.).
11. Panchapakesan J, Hourihan F, Mitchell P. Prevalence of pterygium and pinguecula: The Blue Mountains Eye Study. Aust N Z J Ophthalmol 1998; 26(1): S2.5. doi: 10.1111/j.1442-9071.1998.tb01362.x
12. Wong TY, Foster PJ, Johnson GJ, Seah SK, Tan DT. The prevalence and risk factors for pterygium in an adult Chinese population in Singapore: The Tanjong Pagar survey. Am J Ophthalmol 2001; 131(2): 176-183. doi: 10.1016/s0002-9394(00)00703-0
13. Gazzard G, Saw SM, Farook M, Koh D, Widjaja D, Chia SE, et al. Pterygium in Indonesia: Prevalence, severity and risk factors. Br J Ophthalmol. 2002; 86(12): 1341-1346. doi: 10.1136/bjo.86.12.1341
14. Zhong H, Cha X, Wei T, Lin X, Li X, Li J, et al. Prevalence of and risk factors for pterygium in rural adult chinese populations of the Bai nationality in Dali: The Yunnan Minority Eye Study. Invest Ophthalmol Vis Sci. 2012; 53(10): 6617-6621. doi: 10.1167/iovs.11-8947
15. Asokan R, Venkatasubbu RS, Velumuri L, Lingam V, George R. Prevalence and associated factors for pterygium and pinguecula in a South Indian population. Ophthalmic Physiol Opt. 2012; 32(1): 39-44. doi: 10.1111/j.1475-1313.2011.00882.x
16. Marmamula S, Khanna RC, Rao GN. Population-based assessment of prevalence and risk factors for pterygium in the South Indian state of Andhra Pradesh: The Andhra Pradesh Eye Disease Study. Invest Ophthalmol Vis Sci. 2013; 54(8): 5359-5366. doi: 10.1167/iovs.13-12529
17. Chang X, Wang M, An L. Variations of pterygium prevalence by age, gender and geographic characteristics in China: A systematic review and meta-analysis. PLoS One. 2017; 12(3): e0174587. doi: 10.1371/journal.pone.0174587
18. Norn MS. Prevalence of pinguecula in Greenland and in Copenhagen, and its relation to pterygium and spheroid degeneration. Acta Ophthalmol (Copenh) 1979; 57(1): 96-105. doi: 10.1111/j.1755-3768.1979.tb06664.x
19. Shiroma H, Higa A, Sawaguchi S, Iwase A, Tomidokoro A, Amano S, et al. Prevalence and risk factors of pterygium in a southwestern island of Japan: The Kumejima Study. Am J Ophthalmol 2009; 148(5): 766-771.e1. doi: 10.1016/j.ajo.2009.06.006
20. McCarty CA, Fu CL, Taylor HR. Epidemiology of pterygium in Victoria, Australia. Br J Ophthalmol. 2000; 84(3): 289-292. doi: 10.1136/bjo.84.3.289
21. Liang QF, Xu L, Jin XY, You QS, Yang XH, Cui TT. Epidemiology of pterygium in aged rural population of Beijing, China. Chin Med J. 2010; 123(13): 1699-1701
22. Nemesure B, Wu SY, Hennis A, Leske MC. Nine-year incidence and risk factors for pterygium in the Barbados Eye Studies. Ophthalmology. 2008; 115(12): 2153-2158. doi: 10.1016/j.ophtha.2008.08.003
23. Rezvan F, Hashemi H, Emamian MH, Kheirkhah A, Shariati M, Khabazkhoob M, et al. The prevalence and determinants of pterygium and pinguecula in an urban population in Shahroud, Iran. Acta Med Iran. 2012; 50(10): 689-696.
24. Lu P, Chen X, Kang Y, Ke L, Wei X, Zhang W. Pterygium in Tibetans: A population-based study in China. Clin Exp Ophthalmol. 2007; 35(9): 828-833. doi: 10.1111/j.1442-9071.2007.01630.x
25. West S, Munoz B. Prevalence of pterygium in Latinos: Proyecto VER. Br J Ophthalmol. 2009; 93(10): 1287-1290. doi: 10.1136/bjo.2008.152694
26. Lu J, Wang Z, Lu P, Chen X, Zhang W, Shi K, et al. Pterygium in an aged Mongolian population: A population-based study in China. Eye (Lond). 2009; 23(2): 421-427. doi: 10.1038/sj.eye.6703005
27. Luthra R, Nemesure BB, Wu SY, Xie SH, Leske MC, Barbados Eye Studies Group. Frequency and risk factors for pterygium in the Barbados Eye Study. Arch Ophthalmol. 2001; 119(12): 1827- 1832. doi: 10.1001/archopht.119.12.1827
28. Obukhova MP, Gainullina MK, Valeeva ET, Volgareva AD, Khafizova AS. The visual condition of the rural population of the Republic of Bashkortostan based on the preventive examination results. Occupational Health and Human Ecology. 2019; 1(17): 23-28. (In Russ.). doi: 10.24411/2411-3794-2019-10004
29. Crewe JM, Threlfall T, Clark A, Sanfilippo PG, Mackey DA. Pterygia are indicators of an increased risk of developing cutaneous melanomas. Br J Ophthalmol. 2018; 102(4): 496-501. doi: 10.1136/bjophthalmol-2017-310686
30. Saw SM, Tan D. Pterygium prevalence, demography and risk factors. Ophthalmic Epidemiol. 1999; 6(3): 219-228. doi: 10.1076/opep.6.3.219.1504
31. Cajucom-Uy H, Tong L, Wong TY, Tay WT, Saw SM. The prevalence of and risk factors for pterygium in an urban Malay population: The Singapore Malay Eye Study (SiMES). BrJ Ophthalmol. 2010; 94(8): 977-981. doi: 10.1136/bjo.2008.150847
32. Viso E, Gude F, Rodriguez-Ares MT. Prevalence of pinguecula and pterygium in a general population in Spain. Eye (Lond). 2011; 25(3): 350-357. doi: 10.1038/eye.2010.204
Review
For citations:
Bikbov M.M., Surkova V.K., Kazakbaev R.A. Regional features of the epidemiology of pterygium in the Republic of Bashkortostan. Acta Biomedica Scientifica. 2022;7(1):82-89. (In Russ.) https://doi.org/10.29413/ABS.2022-7.1.10