Time-related OCT-A changes in preclinical retinopathy and their association with systemic factors
https://doi.org/10.29413/ABS.2021-6.6-1.14
Abstract
Background. Optical coherence tomography angiography (OCT-A) is a promising tool for the detection of microvascular impairment at the preclinical stage of diabetic retinopathy (DR). Evaluation of dynamic OCT-A changes and their association with systemic factors can help to reveal early biomarkers of DR progression.
Aim: to evaluate time-related OCT-A changes and their association with systemic factors in type 1 diabetes mellitus (DM1) patients with no apparent DR
Materials and methods. 38 DM1 patients with no apparent DR and 39 healthy volunteers were included in the study. All participants underwent 7-fi eld fundus photography, OCT and OCT-A. We analyzed OCT-A parameters (foveal avascular zone (FAZ) area (mm2), acircularity index (AI), vessel density (VD), skeletonized density (SD)) as well as the results of blood and urea tests.
Results. After one year of observation, AI was significantly higher (р = 0.005) and VD0–300 was signifi cantly lower in superfi cial vascular plexus (SVP, p < 0.0001) and deep capillary plexus (DCP, р = 0.032) in DM1 patients. We have also registered a positive correlation between AI and triglycerides (TG) level (r = 0.627, p = 0.007) as well as a negative correlation between ketones and VD (SVP VD0–300: r = –0.695, p = 0.030; intermediate capillary plexus (ICP, VD0–300: r = –0.551, p = 0.041; DCP, VD0–300: r = –0.704, p = 0.003; SVP, VD300–600: r = –0.853, p = 0.001).
Conclusions. After one year of observation, we have registered an increase in AI level and a decline in VD in SVP and DCP which can be the earliest signs of DR progression. A signifi cant correlation between these parameters and systemic factors indicates their role as potential DR biomarkers.
About the Authors
A. N. Stulova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Postgraduate, Ophthalmology Department
Lomonosova ave. 27/1, Moscow 119991, Russian Federation
N. S. Semenova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Cand. Sc. (Med.), Associate Professor at the Ophthalmology Department
Lomonosova ave. 27/1, Moscow 119991, Russian Federation
A. V. Zheleznyakova
Endocrinology Research Centre
Russian Federation
Russian Federation
Cand. Sc. (Med.), Senior Research Officer
Dmitrya Ulyanova str. 11, Moscow 117036, Russian Federation
V. S. Akopyan
Lomonosov Moscow State University
Russian Federation
Russian Federation
Dr. Sc. (Med.), Professor, Head of the Ophthalmology Department
Lomonosova ave. 27/1, Moscow 119991, Russian Federation
D. V. Lipatov
Endocrinology Research Centre;
Peoples Friendship University of Russia
Russian Federation
Russian Federation
Dr. Sc. (Med.), Professor, Head of the Department of Diabetic Retinopathy
Dmitrya Ulyanova str. 11, Moscow 117036, Russian Federation
Miklukho-Maklaya str. 6, Moscow 117198, Russian Federation
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Review
For citations:
Stulova A.N., Semenova N.S., Zheleznyakova A.V., Akopyan V.S., Lipatov D.V. Time-related OCT-A changes in preclinical retinopathy and their association with systemic factors. Acta Biomedica Scientifica. 2021;6(6-1):122-127. (In Russ.) https://doi.org/10.29413/ABS.2021-6.6-1.14
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