Роль лизосом в онкогенезе: акцент на деградацию внеклеточного матрикса
Аннотация
Лизосомы – многофункциональные клеточные органеллы, которые не только обеспечивают деградацию макромолекул люменальными кислыми гидролазами, но также участвуют в регуляции клеточного метаболизма, поддержании ионного гомеостаза и индукции программируемой клеточной гибели. Особый интерес вызывает изучение этого компартмента при различных патологических состояниях, в том числе при развитии онкологических заболеваний различного генеза. Метаболические и морфологические изменения клеток в процессе онкогенеза приводят к рН-зависимому перераспределению лизосом в пределах клетки, сопровождающемуюся секрецией лизосомальных протеаз катепсинов во внеклеточное пространство. Цистеиновые, сериновые и аргининовые катепсины, выделяемые как опухолевыми клетками, так и клетками, ассоциированными с опухолью, катализируют расщепление различных компонентов внеклеточного матрикса и базальной мембраны или протеолитически активируют другие ферменты, также участвующие в этом процессе. При этом лизосомальные протеазы непосредственно влияют на способность клеток к инвазии и метастатический потенциал опухолевого образования. Кроме того, было продемонстрировано прогностическое значение некоторых катепсинов (особенно катепсинов B, K и D), количество и активность которых в опухолевой ткани и в её микроокружении сопряжены со злокачественностью образования, а также с плохим прогнозом по выживаемости пациентов и возможностью возникновения рецидивов.
Об авторах
И. С. Трухан
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия
Россия
кандидат биологических наук, старший научный сотрудник
664003, г. Иркутск, ул. Борцов Революции, 1, Россия
Н. Н. Дремина
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия
Россия
кандидат биологических наук, старший научный сотрудник
664003, г. Иркутск, ул. Борцов Революции, 1, Россия
И. А. Шурыгина
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия
Россия
доктор медицинских наук, профессор РАН, заместитель директора по научной работе
664003, г. Иркутск, ул. Борцов Революции, 1, Россия
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Для цитирования:
Трухан И.С., Дремина Н.Н., Шурыгина И.А. Роль лизосом в онкогенезе: акцент на деградацию внеклеточного матрикса. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2020;5(6):77-87. https://doi.org/10.29413/ABS.2020-5.6.9
For citation:
Trukhan I.S., Dremina N.N., Shurygina I.A. The Role of Lysosomes in the Cancer Progression: Focus on the Extracellular Matrix Degradation. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2020;5(6):77-87. (In Russ.) https://doi.org/10.29413/ABS.2020-5.6.9
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