A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
https://doi.org/10.29413/ABS.2020-5.5.14
Abstract
Background. The ability to control regeneration processes is a key link in the development of methods for treating patients with post-traumatic disorders of reparative osteogenesis.
Aim of the study. To evaluate the effectiveness of the fusion of the tibia by local application of the interferon-beta preparation with autogenous bone marrow punctate in post-traumatic disorders of reparative regeneration.
Material and methods. The analysis of the effectiveness of clinical application of autogenous bone marrow with interferon-beta-1b in 64 patients with delayed consolidation and pseudarthrosis of the tibia was carried out. All patients underwent external bone fixation. In order to optimize reparative osteogenesis during the operation, a mixture containing 3–4 ml of bone marrow with 8 million IU/0.5 ml of interferon beta-1b solution was injected locally into the interfragmental space.
Results. With puncture local injection of interferon-beta with punctate of autogenous bone marrow with delayed consolidation, fusion of the tibial fracture was achieved in 100 % of cases. In patients with a diagnosis of a pseudarthrosis of the tibia, a positive result was achieved in 90.3 % of cases. Thus, the local application of autogenous bone marrow together with the interferon-beta preparation made it possible to achieve bone fusion in post-traumatic disorders of bone regeneration in 95.2 % of cases.
Conclusion. With delayed consolidation and developing hypertrophic pseudoarthrosis in conditions of stable fixation with anatomical reposition of fragments, puncture autotransplantation of a mixture of bone marrow with a solution of interferon-beta is proposed.
About the Authors
V. F. Lebedev
Irkutsk State Medical University
Russian Federation
Russian Federation
Cand. Sc. (Med.), Associate Professor at the Department of Traumatology and Orthopedy
L. A. Dmitriyeva
Irkutsk Scientific Centre of Surgery and Traumatology
Russian Federation
Russian Federation
Cand. Sc. (Med.), Senior Research Officer at the Laboratory of Cellular Pathology and Biochemistry
Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation
I. A. Shuruguna
Irkutsk Scientific Centre of Surgery and Traumatology
Russian Federation
Russian Federation
Dr. Sc. (Med.), Professor of the Russian Academy of Sciences
P. N. Khaziyev
Medical Unit of the Irkutsk Aviation Production Association
Russian Federation
Russian Federation
Head of Traumatology Unit
Zhukova str. 9, Irkutsk 664002, Russian Federation
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Review
For citations:
Lebedev V.F., Dmitriyeva L.A., Shuruguna I.A., Khaziyev P.N. A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia. Acta Biomedica Scientifica. 2020;5(5):107-111. (In Russ.) https://doi.org/10.29413/ABS.2020-5.5.14
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