Comparative Assessment of Changes in the Blood Coagulation System in Rats When Exposed to Organic Boron Compounds of Various Chemical Structures

Abstract

Background. Despite the available information on the clinical manifestations of acute and chronic intoxication with boron compounds, no clear evidence was found among studies to research the effect of boron compounds with different chemical structures on key factors of the blood coagulation system. The data are presented in full for the first time.
Aim of the study. Identification of possible signs of the effect of boron compounds on selected indicators of hemostasis in laboratory animals and their characteristics depending on the chemical structure of the compounds.
Methods. Modern methods of studying hemostasis are used. Nonlinear rats were chosen as the experimental biological model. Once through the mouth, in the maximum tolerated dose, the following drugs were administered: isopropylmethacarborane, 1,2-di(oxymethyl)orthocarborane, 1,7-di(oxymethyl)methacarborane, polyethylammonium triethylammonium salt, boric acid. Research conducted against a background of dynamic control.
Results. Materials were obtained that testify to the effect of boron compounds under the conditions of this experiment on factors of the blood coagulation system. The differences in this effect are established in connection with the chemical structure of the compounds, which are especially pronounced after the introduction of methacarboranes. The effect of orthocarborane and the polyethylammonium triethylammonium salt on factors was less significant. An important fact is that boric acid per se, by its effect on the blood coagulation system, turned out to be less effective than other compared compounds.
Conclusion. The polytropy of the toxic effect of boron compounds of different chemical structures was confirmed, including with the involvement of the blood coagulation system, but with the essential features of each of them under conditions of a single exposure to laboratory animals in the maximum tolerated dose.