Application of the Fibrous Autograft in Posttraumatic Bone Regeneration of the Lower Jaw
https://doi.org/10.29413/ABS.2019-4.1.25
Abstract
The search for new types of bone substitutes is one of the topical problems of biology and medicine. The paper considered the role of fibrous autograft in reparative bone regeneration in the rat’s lower jaw model. Thirty Wistar rats were taken in the experiment: 15 in the experimental and 15 in the control group. Fibrous autograft was formed on the cellophane basis under the skin on the back of rats. Injury in the lower jaw with a diameter of 2 mm was formed and a fibrous graft was placed in injuries in the experimental group. Five animals from each groups were sacrificed at the first, third and fifth weeks of the experiment. The object of the further research was the samples of the lower jaws stained according to Van Gieson. Histological examination of the bone defect of the experimental group after 1 week showed absence of bone fragments and formation of fibrous callosity in the trauma zone. Further study of regenerate at the 3rd and the 5th weeks showed accelerated bone wound healing in the experimental group (compared to the control group). Thus, the autograft stimulates the process of bone tissue restoration in the area of the defect of the lower jaw model.
About the Authors
Vladimir A. Usachev
Ural Federal University
Russian Federation
Postgraduate Student at the Institute of Natural Sciences and Mathematics
Russian Federation
Postgraduate Student at the Institute of Natural Sciences and Mathematics
Olga S. Artashyan
Ural Federal University;
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Russian Federation
Cand. Sc. (Biol.), Senior Research Officer at the Laboratory of Immunophysiology and Immunopharmacology, Institute of Immunology and Physiology
Russian Federation
Cand. Sc. (Biol.), Senior Research Officer at the Laboratory of Immunophysiology and Immunopharmacology, Institute of Immunology and Physiology
Vyacheslav V. Kotomtsev
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Russian Federation
Dr. Sc. (Biol.), Leading Research Officer at the Laboratory of Immunophysiology and Immunopharmacology, Institute of Immunology and Physiology
Russian Federation
Dr. Sc. (Biol.), Leading Research Officer at the Laboratory of Immunophysiology and Immunopharmacology, Institute of Immunology and Physiology
Gleb S. Senkin
Ural State Medical University
Russian Federation
Student at the Preventive Medicine Faculty
Russian Federation
Student at the Preventive Medicine Faculty
Daria A. Solosina
Ural State Medical University
Russian Federation
Student at the Preventive Medicine Faculty
Russian Federation
Student at the Preventive Medicine Faculty
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Review
For citations:
Usachev V.A., Artashyan O.S., Kotomtsev V.V., Senkin G.S., Solosina D.A. Application of the Fibrous Autograft in Posttraumatic Bone Regeneration of the Lower Jaw. Acta Biomedica Scientifica. 2019;4(1):162-165. (In Russ.) https://doi.org/10.29413/ABS.2019-4.1.25
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