Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
Abstract
Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't increase risks (OR = 1,36 (95% CI = 0,83-2,2); р = 0,01). Smoking 5 times increases risk of myocardial infarction (OR = 5,16 (95% CI = 1,05-25,39); p < 0,05) in homozygotes, and 1,5 times (OR = 1,46 (95% CI = 0,77-2,78); p < 0,05) - in heterozygotes of 511Т/С lL1B. Haplotype СТ (rs1143634 - rs16944) of IL1B is connected with the decrease of risk of myocardial infarction in nonsmoking patients (OR = 0,43 (95% DI = 0,19-0,95); р < 0,01).
About the Authors
M. V. Khutornaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
A. V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Y. V. Bayrakova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
A. S. Golovkin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
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Review
For citations:
Khutornaya M.V., Ponasenko A.V., Bayrakova Y.V., Golovkin A.S. Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction. Acta Biomedica Scientifica. 2014;(5):30-33. (In Russ.)
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