ABOUT THE OPPORTUNITIES TO Influence MICROORGANISMS ON THE IRON HOMEOSTASIS IN THE HOST ORGANISM (Literature review)
Abstract
Iron homeostasis, aimed at depriving the pathogen of available iron, takes an important role in protecting human body against pathogens. When infection occurs, microorganisms must overcome iron deficiency in a host organism. This review describes microorganisms' ways of gaining iron in the host organism, presents present-day data on changing of iron homeostasis during infection and the main regulators of this process. Theoretical substantiation was given of the possibility of microorganisms' influence on iron homeostasis due to ability to inactivate hepcidin - antihepcidin activity.
About the Authors
V. V. Leonov
Khanty-Mansiysk State Medical Academy
Russian Federation
Russian Federation
N. A. Kurlovich
Consultative-Diagnostic Policlinic named after E.M. Niginsky
Russian Federation
Russian Federation
L. V. Leonova
Khanty-Mansiysk State Medical Academy
Russian Federation
Russian Federation
N. M. Fateeva
Tyumen State University
Russian Federation
Russian Federation
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Review
For citations:
Leonov V.V., Kurlovich N.A., Leonova L.V., Fateeva N.M. ABOUT THE OPPORTUNITIES TO Influence MICROORGANISMS ON THE IRON HOMEOSTASIS IN THE HOST ORGANISM (Literature review). Acta Biomedica Scientifica. 2014;(1):120-124. (In Russ.)
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