PROSTAGLANDIN Е2 AS GULL TAPEWORM POTENTiAL iMMUNOMODULATOR
Abstract
This article is devoted to investigation of prostaglandin E2 as potential immunomodulator of gull tapeworm. This parasite has an important epizootic and epidemiological significance in the Lake Baikal and. its basin. Using confocal microscopy, it was revealed that prostaglandin. E2 is produced and. secreted with specialized frontal glands in the organism of gull tapeworm. Using the method of leukocyte culture, the influence of prostaglandin. E2 on immunological reaction of fishes was investigated (by way of example of three-spined stickleback). This immunomodulator decreased the absolute number of leucocytes and. percentage of lymphocytes. Despite of total leukocyte respiratory-burst activity decreasing, respiratory-burst activity per 1 granulocyte remains constant.
About the Authors
I. A. Kutyrev
Institute of General and Experimental Biology SB RAMS
Russian Federation
Russian Federation
N. M. Biserova
Lomonosov’s Moscow State University
Russian Federation
Russian Federation
J. P. Scharsack
University of Munster
Russian Federation
Russian Federation
J. .. Kurtz
University of Munster
Russian Federation
Russian Federation
References
1. Давыдов В.Г., Бисерова Н.М. Морфология двух типов фронтальных желез Grillotiaerinaceus (Cestoda:Trypanorhyncha) // Паразитология. -1985. - Т. 19, № 1. - С. 32-37.
2. Куперман Б.И. Функциональная морфология низших цестод. - Л.: Наука, 1988. - 167 с.
3. Русинек О.Т. Паразиты рыб озера Байкал (фауна, сообщества, зоогеография, история формирования). - М.: КМК, 2007. - 600 с.
4. Andersen K.I. Ultrastructural Studies on Diphyllobothrium ditremum and D. dendriticum (Cestoda, Pseudophyllidea) // Parasitol. Res. - 1975. -Vol. 46. - P. 253-264.
5. Habitat specific adaptation of immune responses of stickleback (Gasterosteusaculeatus) lake and river ecotypes / J.P. Scharsack [et al.] // Proc. R. Soc. Lond. - 2007. - Vol. 274. -P. 1523- 1532.
6. Hewitson J.P., Grainger J.R., Maizels R.M. Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity // Mol. Biochem. Parasit. - 2009. - P. 1-11.
7. Modulation of the host's immune response by schistosome larvae / S.J. Jenkins [et al.] // Parasite Immunol. - 2005. - Vol. 27. - P. 385-393.
8. Scharsack J.P., Koch K., Hammerschmidt K. Who is in control of the stickleback immune system: interactions between Schistocephalus solidus and its specific vertebrate host // Proc. R. Soc. Lond. -2007. - Vol. 274. - P. 3151-3158.
Review
For citations:
Kutyrev I.A., Biserova N.M., Scharsack J.P., Kurtz J... PROSTAGLANDIN Е2 AS GULL TAPEWORM POTENTiAL iMMUNOMODULATOR. Acta Biomedica Scientifica. 2012;(5(1)):245-249. (In Russ.)
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