IMPACT OF BONE MARROW-DERIVED MULTIPOTENT MESENCHYMAL STROMAL CELLS ON SPEED OF POLYCAPROLACTONE AND POLYHYDROXYALKANOATE SCAFFOLDS BIODEGRADATION
Abstract
The impact of bone marrow-derived multipotent mesenchymal stromal cells of a bone brain (MSCs BB) on the speed of polycaprolactone and polyhydroxyalkanoate scaffolds biodegradation was studied. The presence of cells on the scaffolds surface was found to catalyze their resorption. 2 months after MSCs-covered scaffolds had. been subcutaneously implanted in rats they degraded completely while scaffolds, which had no MSCs cover, had partially resorbed by that time. The obtained results make necessary further studying of MSCs impact mechanisms on biopolymers resorption speed.
About the Authors
L. V. Antonova
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
A. Y. Burago
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
V. G. Matveyeva
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
Y. A. Kudryavtseva
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
M. V. Nasonova
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
Y. G. Toropova
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
E. A. Velikanova
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
A. S. Golovkin
Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
Antonova L.V., Burago A.Y., Matveyeva V.G., Kudryavtseva Y.A., Nasonova M.V., Toropova Y.G., Velikanova E.A., Golovkin A.S. IMPACT OF BONE MARROW-DERIVED MULTIPOTENT MESENCHYMAL STROMAL CELLS ON SPEED OF POLYCAPROLACTONE AND POLYHYDROXYALKANOATE SCAFFOLDS BIODEGRADATION. Acta Biomedica Scientifica. 2012;(3(2)):249-252. (In Russ.)
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