MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
Abstract
Molecular aspects of carcinogenesis of endometrium with analysis of scientific literature and own experimental data are considered. It was shown that in this process are involved as well classical signal transduction pathways like PI3K, Wnt, Bcl-2-regulated apoptosis as hormonal pathways from ERα to target genes. Gene expression of apoptosis inhibitor Bcl-2 was in 6 folds higher in malignant tumors in comparison with non cancer tissue. Expression level of ERα gene was higher in cancer tissue than in adjacent non-tumor endometrium. Matrix metallo-proteinases MMR-3, MMR-9 and angiogenesis gene Il-8 expressed mainly in malignant endometrial tissues, but not in non-cancer tissues that considers these genes as suitable candidates for the characteristic of endometrial carcinoma. Thus, Bcl-2, IL8, ERα and MMPs 2 proteins can be appropriate markers of endometrial carcinoma together with the members of PI3K- and Wnt-signal pathways like PTEN and β-catenin.
About the Authors
L. F. Gulyaeva
Institute of Molecular Biology and Biophysics, Siberian Branch of Russian Academy of Medical Sciences; Novosibirsk State University
Russian Federation
Russian Federation
S. E. Krasilnikov
Novosibirsk State University; Novosibirsk Regional Oncological Hospital
Russian Federation
Russian Federation
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Review
For citations:
Gulyaeva L.F., Krasilnikov S.E. MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA. Acta Biomedica Scientifica. 2012;(3(1)):110-115. (In Russ.)
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