The relationship between past coronavirus infection and the content of serum interleukins in diseases of the nervous system
https://doi.org/10.29413/ABS.2025-10.3.7
Abstract
Background. The mediators of inflammation, which is the most important mechanism for the development of coronavirus infection, accompanied by various complications from the nervous system, both in the acute period of the disease and in the long term, are a group of interleukins.
The aim. To clarify the relationship between previous coronavirus infection and the content of serum interleukins in diseases of the nervous system.
Methods. The study involved 146 patients with acute cerebrovascular accidents (32), diseases of the central (60) and peripheral nervous system (54), of which 47 had COVID-19. The comparison group included 54 people comparable in age and gender without clinical signs of acute and chronic diseases. Using diagnostics from Vector Best, the content of interleukins 6, 8, 10 and 18 was determined by ELISA.
Results. In the blood of patients with diseases of the nervous system, the content of detectable interleukins is increased, the most characteristic of interleukin 6, the content of which in the blood of patients depended on the nature of the disease and was higher in patients who had recovered from COVID-19.
In the blood of patients with diseases of the nervous system, the content of detectable interleukins is increased, most characteristic of interleukin 6, the content of which in the blood of patients depended on the nature of the disease and was higher in patients who had recovered from COVID-19.
Conclusion. A greater intensity of the inflammatory process was established in patients who had recovered from COVID-19, manifested in a higher content of proinflammatory interleukins in relation to patients who have not recovered from coronavirus infection.
About the Author
P. E. Borodin
Amur State Medical Academy of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Pavel E. Borodin – neurologist, 5th year postgraduate student of the Chemistry Department
Gorky st., 95, Amur region, 675001 Blagoveshchensk
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For citations:
Borodin P.E. The relationship between past coronavirus infection and the content of serum interleukins in diseases of the nervous system. Acta Biomedica Scientifica. 2025;10(3):70-79. (In Russ.) https://doi.org/10.29413/ABS.2025-10.3.7
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