ВПЧ-ассоциированный рак шейки матки: современное состояние и перспективы

Ежегодно в мире диагностируется 570 000 новых случаев рака шейки матки (РШМ), и 311 000 человек погибают от этого заболевания. РШМ – четвёртый по распространённости вид рака и, соответственно, четвёртая по  распространённости причина смерти от рака у женщин во всём мире. Многочисленные данные о возникновении и развитии РШМ свидетельствуют об ассоциации в большинстве случаев (до 90 %) с вирусами папилломы человека (ВПЧ) высокого канцерогенного риска (ВКР).

В свою очередь стратегии профилактики РШМ основаны на скрининге, а смертельные исходы от данной онкопатологии представляется возможным предотвратить путём проведения вакцинопрофилактики и лечения при раннем обнаружении заболевания.

В представленном обзоре большое внимание уделяется актуальным в настоящее время вопросам выявления и профилактики ВПЧ-ассоциированных патологий, в частности рака шейки матки, с целью обобщения и анализа последних международных литературных данных по данной проблематике. В результате проведения настоящего исследования показано, что для стран, реализующих Национальную программу вакцинации против ВПЧ ВКР, зарегистрировано снижение заболеваемости как патологиями шейки матки различной степени тяжести, так и другими онкозаболеваниями, ассоциированными с носительством данного вируса.

Несмотря на то, что эффективное использование накопленного на сегодняшний день опыта и будущих достижений вакцинопрофилактики папилломавирусной инфекции может позволить всем странам перейти к высокому уровню охвата, который необходим для окончательной ликвидации ВПЧ-ассоциированной патологии, полученные результаты также свидетельствуют о том, что путь к полной ликвидации рака шейки матки как глобальной проблемы общественного здравоохранения может оказаться чрезвычайно трудным в силу ряда существующих ограничений.

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