Перспективы создания антимикробных препаратов на основе наночастиц меди и оксидов меди
Аннотация
Распространение полирезистентных к современным антимикробным препаратам штаммов микроорганизмов по-прежнему остаётся актуальной проблемой лечения и профилактики инфекционных заболеваний и общественного здравоохранения в целом.
В настоящее время активно изучается возможность применения нанопрепаратов металлов в различных областях медицины. Наночастицы металлов и оксидов металлов являются перспективными антимикробными агентами и вызывают растущий интерес благодаря своей эффективности. Металлические частицы меди в наномасштабе продемонстрировали высокую антимикробную активность против различных видов грамположительных и грамотрицательных бактерий, а также грибков. Учитывая потенциал наночастиц меди и её оксидов в противомикробной терапии, мы представляем обзор современного состояния исследований, связанных с их антимикробными свойствами, рассмотрением механизмов действия, ключевых факторов, влияющих на антимикробную активность, в том числе полимерной матрицы. Рассмотрены вопросы токсичности и устойчивости к меди. Показано преимущество наночастиц меди и оксидов меди перед другими металлическими наночастицами.
Обобщённые в этом обзоре исследования показали перспективность наночастиц меди в создании новых антимикробных препаратов, которые в будущем могут быть использованы для контроля, профилактики и лечения различных заболеваний.
Ключевые слова
медь,
оксиды меди,
наночастицы,
нанокомпозиты,
антимикробная активность,
патогенные микроорганизмы,
цитотоксичность
Об авторах
А. В. Невежина
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия
Россия
младший научный сотрудник лаборатории клеточных технологий и регенеративной медицины
664003, г. Иркутск, ул. Борцов Революции, 1, Россия
Т. В. Фадеева
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия
Россия
доктор биологических наук, ведущий научный сотрудник лаборатории клеточных технологий и регенеративной медицины
664003, г. Иркутск, ул. Борцов Революции, 1, Россия
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Рецензия
Для цитирования:
Невежина А.В., Фадеева Т.В. Перспективы создания антимикробных препаратов на основе наночастиц меди и оксидов меди. Acta Biomedica Scientifica. 2021;6(6-2):37-50. https://doi.org/10.29413/ABS.2021-6.6-2.5
For citation:
Nevezhina A.V., Fadeeva T.V. Prospects for the creation of antimicrobial preparations based on copper and copper oxides nanoparticles. Acta Biomedica Scientifica. 2021;6(6-2):37-50. (In Russ.) https://doi.org/10.29413/ABS.2021-6.6-2.5
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