Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection

Abstract

The aim of the research was to explore range of skin and mucous membrane pathology in patients with HIV infection in Sverdlovsk region, assess the impact on it the severity of immunodeficiency, systemic receiving antiretroviral drugs. The study included 459 patients with HIV infection. The patients were divided into two groups: Group 1 (core) - patients on antiretroviral therapy (ART), 133 people, group 2 (control group) - 326 HIV-persons who are not receiving ART. The control group is represented by two subgroups: 2A - patients with a level of CD4+ T-lymphocyte cells > 350/ßl (153 patients) and 2B -173 HIV-positive with the amount of CD4+ cells less than 350/ßl. Among HIV-infected patients not receiving ART, with the level of CD4+ T-cells below 350 cells/ßl were significantly more lesions detected candida, hairy leukoplakia tongue (p < 0,01), seborrheic dermatitis, psoriasis (p < 0.05), when CD4+ > 350 cells/ßl - skin xerosis (p < 0,05). On the background of the systematic intake of antiretroviral drugs we detected reduced frequency of candidiasis (from 21.5 % to 6.8 %), of herpes zoster (from 6.1 % to 0.8 %), and of hairy leukoplakia (absent on the background of ART), on the other hand we revealed increase occurrence of impairments caused by human papilloma virus.