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Acta Biomedica Scientifica (East Siberian Biomedical Journal)

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Карбапенемазы как фактор устойчивости к антибактериальным препаратам

https://doi.org/10.29413/ABS.2020-5.6.11

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Аннотация

Антибиотические препараты используются для лечения и профилактики бактериальных инфекций во всём мире. Появление и распространение бактериальной устойчивости к карбапенемам является в настоящее время реальной угрозой, определяющей необходимость её своевременного обнаружения и подавления. В глобальном списке приоритетных патогенов ВОЗ 2017 года к категории наивысшего приоритета отнесены  устойчивые к карбапенемам Enterobacteriaceae, Pseudomonas aeruginosa и Acinetobacter baumannii. Количество известных карбапенемаз постоянно увеличивается, но наиболее распространены IMP-тип, VIM-тип, NDM-тип, КРС-тип и ОХА-тип. Карбапенемазы принадлежат к молекулярному классу B (металло-β-лактамазы) или молекулярным классам A и D (сериновые карбапенемазы). Гены, кодирующие карбапенемазы, входят в состав мобильных генетических элементов, что способствует их быстрому внутри- и межвидовому переносу. В связи с этим целью данного обзора является ознакомление с актуальной  информацией о классификации и характеристике карбапенемаз, способах преодоления  распространения резистентности к карбапенемам. При этом в статье уделено внимание не  только возбудителям инфекций, но и тем переносчикам карбапенемаз, которые не были замечены в качестве инфекционных агентов, поскольку они так же могут влиять на эволюцию генов резистентности.

Об авторе

А. В. Невежина
ФГБНУ «Иркутский научный центр хирургии и травматологии»
Россия

младший научный сотрудник лаборатории клеточных технологий и регенеративной медицины

664003, г. Иркутск, ул. Борцов Революции, 1, Россия



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Для цитирования:


Невежина А.В. Карбапенемазы как фактор устойчивости к антибактериальным препаратам. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2020;5(6):95-105. https://doi.org/10.29413/ABS.2020-5.6.11

For citation:


Nevezhina A.V. Carbapenemases as factors of Resistance to Antibacterial Drugs. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2020;5(6):95-105. (In Russ.) https://doi.org/10.29413/ABS.2020-5.6.11

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