Change of Lipid Peroxidation System – Antioxidant Protection Parameters in Adolescents with Obesity and Fatty Hepatosis

Background. Spread of childhood obesity is associated with social and economic factors of modern lifestyle that alter food preferences and lead to sedentary life. Nowadays fatty hepatosis is considered a hepatic manifestation of the metabolic syndrome, which is linked to the rising prevalence of obesity among the population. There is evidence of a correlation between metabolic disorders and oxidative stress reactions.

Aims. To study characteristics of lipid peroxidation system and antioxidant defense processes in adolescents with fatty hepatosis.

Materials and methods. We examined 15 adolescents with obesity and fatty hepatosis, 20 adolescents with obesity and without fatty hepatosis, and 20 apparently healthy adolescents, who formed the control group. Spectrophotometric and fluorometric methods were used in the research.

Results. We found that some components of antioxidant status of adolescents with obesity and fatty hepatosis were decreased, both in comparison with the group with obesity without hepatosis and control group.

Conclusions. It is recommended that patients with obesity and fatty hepatosis take antioxidants in addition to metabolic therapy.

1. Bekezin VV. Oxidative stress associated with obesity, an early marker of metabolic syndrome in children and adolescents (review). Smolenskiy meditsinskiy al’manakh. 2016; (3): 6-13. (In Russ.)

2. Kolesnikova LI, Rychkova LV, Kolesnikov SI, Darenskaya MA, Gavrilova OA, Kravtsova OV, et al. The evaluation of the lipid peroxidation and antioxidant defense system in adolescent boys with exogenous constitutive obesity using the oxidative stress coefficient. Voprosy pitaniya. 2018; 87(1): 28-34. doi: 10.24411/0042-88332018-10003 (In Russ.)

3. Kolosov YuA, Kolesnikov SI, Anishchenko AP, Burdyukova EV, Gureviсh KG. Overweight and obesity in children, adolescents and adults: causes and risk factors. Patogenez. 2016; 14(4): 9-14. (In Russ.)

4. Savilov ED, Vyborova SA. Stage of adaptation as a health indicator. Gigiena i sanitariya. 2006; (3): 7-8. (In Russ.)

5. Razina AO, Achkasov EE, Runenko SD. Obesity: the modern view of the problem. Ozhirenie i metabolism, 2016; 13(1): 3-8. doi: 10.14341/omet201613-8 (In Russ.)

6. Tutelyan VA, Baturin AK, Kon IYa, Martinchik AN, Uglitskih AK, Korosteleva MM, et al. Prevalence of overweight and obesity among Russian children: multicentre study. Pediatriya. 2014; 93(5): 28-31. (In Russ.)

7. Bolotova NV, Averyanov AP, Zakharova NB, Zotova YuA, Nikitina VV, Stepanova TV. The state of lipid peroxidation and antioxidant defense in obese children. Pediatriya. 2006; 85(4): 11-15. (In Russ.)

8. Kolesnikova LI, Grebenkina LA, Darenskaya MA, Vlasov BYa. Oxidative stress as nonspecific pathogenetic link of reproductive disorders (systematic review). Byulleten’ SO RAMN. 2012; 32(1): 58-66. (In Russi.)

9. Kolesnikova LI, Dolgikh VV, Rychkova LV, Efimova NV, Pogodina AV, Mandzyak TV, et al. Features of physical health of children in industrial cities. Byulleten’ SO RAMN. 2008; (4); 72-76. (In Russ.)

10. Ershova OA, Bairova TA, Kolesnikov SI, Kalyuzhnaya OV, Darenskaya MA, Kolesnikova LI. Oxidative stress and catalase gene. Bulletin of Experimental Biology and Medicine. 2016; 161(3): 400-403. doi: 10.1007/s10517-016-3424-0

11. Kolesnikova LI, Grebenkina LA, Vlasov BY, Darenskaya MA, Labygina AV, Dolgikh MI. Metabolic role of lipid peroxidation processes and antioxidant defense system in the pathogenesis of hypothalamic syndrome. Bulletin of Experimental Biology and Medicine. 2014; 156(3): 303-305. doi: 10.1007/s10517-014-2335-1

12. Kolesnikova LI, Kolesnikov SI, Darenskaya MA, Grebenkina LA, Nikitina OA, Lazareva LM, et al. Activity of LPO processes in women with polycystic ovarian syndrome and infertility. Bulletin of Experimental Biology and Medicine. 2017; 162(3): 320-322. doi: 10.1007/s10517-017-3605-5

13. Kolesnikova LI, Kolesnikov SI, Darenskaya MA, Grebenkina LA, Semenova NV, Osipova EV, et al. Lipid status and predisposing genes in patients with diabetes mellitus type 1 from various ethnic groups. Bulletin of Experimental Biology and Medicine. 2015; 160 (2): 278-280. doi: 10.1007/s10517-015- 3149-5

14. Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond). 2006; 30: 400-418. doi: 10.1038/sj.ijo.0803177

15. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991; 11(1): 81-128. doi: 10.1016/0891-5849(91)90192-6

16. Halliwell B, Long LH, Yee TP, Lim S, Kelly R. Establishing biomarkers of oxidative stress: the measurement of hydrogen peroxide in human urine. Curr Med Chem. 2004; 11(9): 1085- 1092.

17. Dadali VA, Tutelyan VA, Dadali YuV. Carotenoids. Biological activity. Voprosy pitaniya. 2011; (4): 4-18. (In Russ.)

18. Bairova TA, Kolesnikov SI, Kolesnikova LI, Pervushina OA, Darenskaya MA, Grebenkina LA. Lipid peroxidation and mitochondrial superoxide dismutase-2 gene in adolescents with essential hypertension. Bulletin of Experimental Biology and Medicine. 2015; 158(2): 181-184. doi: 10.1007/s10517-014-2717-4